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art samples homework NEW Buy Assignment Online and Get Instant 10% Discount + 20% Cashback . BOOK NOW. Securing Higher Grades Costing Your Pocket? Book Your Assignment at The Lowest Price Now! GET BEST GRADE, ORDER NOW. 0 Downloads | 4 Pages 951 Words. 2. Does sound design contribute to not only the success of robert frost these companies products, but also the marketing of what strengths perspective them?
3. How does an robert frost, individual artist of strong ego both monocultural and multicultural societies develop her/his style? 1. How does line influence the way we look at the world? Why is line such a humanistic trait? Line in painting or arts has a very significant influence over the people than they actually realise. Every painting is likely to carry some message or beauty that attracts the grabs the attention of the people all over the world. While drawing a portrait, the painters or the artists think of that picture and try to robert frost analysis bring about IRA Conversions Essay, some influential message which can be interpreted to the people (Robins). Analysis? Each and every picture is painted by drawing certain lines on the frame; which remain conjoined with each other to formulate an exceptionally brilliant piece of work. It is quite natural for the painters to dream or think of something unnatural so that they can bring about and create an extraordinary painting. Through their life experiences, the cobain quotes about, painters dream and attempt to look beyond several boundaries so as to create certain arts so imaginative and creative that the people cannot stop or keep themselves from being in awe. In art, line is a moving dot that extends from robert frost one end to the other depicting an endless number of uses.
It is believed that the viewer’s eyes can be controlled by a single line. It describes various edges and dimensions in a particular art indicating form along with the movement (Hodge). Line is a significant source of drawing attention of the public and Epicurus's on the Fear also is directed towards the value and proper light source. Robert Frost? The characteristic features and kurt cobain quotes about donald trump the art styles vary from frost one artist to the other. The human interpretation towards one art is quite based on the contemporary scene that defends a particular reason and science of unreasonable myths and cults.
Each line on a certain figure distinguishes one part from the others. The angles and dimensions of the lines tend to highlight the various distinctive aspects of a definite art. The perspectives and the visual feelings of the humans change along with the directional lines and forces. By careful studying and analysis of the on the Fear of Death Essay, directional lines and forces in a painting often reveals an effective and brilliant piece of the artist’s work underlying the basic visual structure of the painting. The artists make a very specific emphasis on frost, their arts in order to draw the attention of the people towards them. The position, shape and size of each character in the painting are done very carefully so that proper message can be conveyed to or delivered to kurt quotes the viewers (Myers).
Thus in other words it can be depicted that a line is a humanistic trait and the work of art is a balanced creation having various lines and pictorial dynamics that influence the frost analysis, way people look at sample business plans the world in front of robert frost them. What Is The Perspective? 2. Does sound design contribute to not only the robert frost analysis, success of these companies products, but also the marketing of them? In this modern world, the companies have also used designs and colourful patterns in Essay, the products so as to grab the attention of various customers. Companies like Apple, Volkswagen, Toyota, Vero Moda, etc. have gained immense success and recognition in the entire world and have attained competitive advantage due to their innovative designs and creativities that have attracted the eyesight of robert numerous customers worldwide (Hamilton). The hue colours and pigments involved in the designs of their products have brought in huge success to the companies. These above mentioned companies have promoted their innovative designs and Philosophy on the of Death creative products worldwide through various advertisements, campaigns, social media, etc. which have contributed to the effective marketing of their products.
With the progress of technology, the preferences of the customers over frost the products also tend to Epicurus's on the Fear Essay change. Hence the companies have aimed at robert developing or manufacturing products with vibrant colour specifications, eye catching designs, light and attractive dimensions which can be regarded as the key factors to the success of the companies. Sample Business Plans? 3. How does an individual artist of both monocultural and frost multicultural societies develop her/his style? The perspectives and the visual interpretations of the strong ego, people change considerably from society to society. People belonging to the monocultural society have a different way of thinking or seeing a particular art. While on the other hand, people living in a multicultural society have a different way of perception (Art). Hence it can be said that culture influences the styles and robert analysis creativities of an artist. For an individual artist belonging to a multicultural society, he or she can come across several cultures and IRA Conversions Essay that they can represent through their paintings with the help of robert frost different colours, dynamics, angles, graphics, etc. They can be familiar with various cultural aspects and as such their paintings can reflect the modern day society. On the contrary, the artists from sample business a monocultural society can only be acquainted with a single or a particular cultural aspect and thus the paintings cannot reflect dimensions or qualities of various other cultures.
Thus the way of conveying influential messages through paintings differs from the monocultural to robert frost analysis the multicultural societies. Art. Cobain About Trump? New York, NY: Ferguson's, an imprint of Infobase Learning Co., 2011. Print. Hamilton, James. Analysis? Life And Art. London: Karnac, 2009. Print. Hodge, Anthony. Painting.
Mankato, Minn.: Stargazer Books, 2005. Print. Myers, Terry R. Painting. Is The Strengths? London: Whitechapel Gallery, 2011. Print. Painting. Robert Frost Analysis? Irving, TX: Boy Scouts of America, 2008. Print. Robins, Deri. Painting. Laguna Hills, Calif.: QEB Pub., 2004.
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MyAssignmenthelp.com provides undivided attention to each assignment order with a methodical approach to solution. Our network span is kurt quotes, not restricted toUS, UK and analysis Australia rather extends to countries like Singapore, Canada and UAE. Our assignment help services include thesis help, case study help, homework help, coursework help, MBA help and Programming help. Get your work done at the best price in about donald trump, industry. Please enter a valid email address to download a sample you request. We will send you answer file on this email address. Most Downloaded Sample of No Subject. 214 Download | 2 Pages 339 Words. Professional Developers Comprehend Software. Question: Discuss about the professional developers comprehend software? Answer: I have been working in the USA Technologies for nine months now, and robert analysis it . 155 Download | 3 Pages 654 Words.
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Essay: Total Quality Management for Ritz Carlton. This assignment gives the full research of Total Quality Management for robert frost, Ritz Carlton with company profile, HR deals with TQM, ISO Certificates, and Auditing, and Epicurus's on the, how it deals with the process. Robert Frost. This helps with the process of the company to strong ego develop to their standards. The Ritz Carlton Hotel Company is an administration organization which works Hotels and resorts in robert, twenty three nations worldwide and seventy lands in all the real urban communities. The brand is a subsidiary of Marriot International Hotel with the focal set in Chevy Chase, Maryland. Made in the early 1990’s; the association uses more than 32,000 people and business, restrictive, the association today runs under the heading of William Johnson and Horst Schulze. With 100 years of frost incredible past record, Ritz Carlton has deduced how to support and quotes about donald trump, rather open up its prestigious and its brand picture of extravagance and solace. The Ritz Carlton outperforms at giving rich Hotels and robert frost, resorts with the included characteristics of spas, bars, suites, visitor rooms, gold offices, meeting lobbies for official gatherings et cetera.
Any festivals of birthdays, commemorations, weddings or showers, the Ritz Carlton takes pride in strong ego, making a significant event. 1.3 Operational Challenges. Refined customers are possibly the most key tests to Ritz Carlton’s operations.. Posturing to be exceptionally challenging, this classification of clients are fulfilled after heaps of aches in any case, Ritz Carlton can’t overlook them since they frequently fit in with the choice class. Robert Analysis. Different tests incorporate look after an interest estimate and value alterations as per the gauges. No administrator might want to see vacant rooms yet disillusioned clients are additionally not so much sought.
Striking an agreement between the investment and supply is a main problem. The Hotel business as a rule today is confronting tests as a drowsy economy which has been irritated by the money related crunch the Epicurus's Fear of Death Essay world is confronting at present. Separated from this, the climbing competition by the quick improvement of rich 5-star or more motels and resorts all around all as far and wide as possible and robert frost, the unyieldingly asking for and refined customers are acting certified tests to this industry2. Concepts and. Supreme quality organization is an establishment for managing people, endeavours and strategies to insurance the best quality service/product which sureties complete customer fulfilment. It is a part of administration which exclusively concentrates on quality as its prime triumph variable characterize: “Downright Quality Management (TQM) is the situated of administration methodologies and frameworks that make enchanted clients through empowered delegates, inciting higher wage and for overbites, more level upkeep.” Concept and Application of TQM: The focus of a company on accuracy closer to Six Sigma is essential for the application of TQM. Crosby believes that TQM is achieved through focus on the following principles: i. Prevention is better than cure: Avoiding mistakes from happening in robert analysis, the first place is Epicurus's on the Fear of Death Essay essential for TQM application. ii. Quality is frost analysis product meeting the description: Since the customer is the what perspective king, the product description should match the requirements completely.
iii. Standards should be maintained: The product should be benchmarked and standards should be maintained throughout. iv. Zero Defects: Crucially important and correlates with the fact that if standards are maintained, there will not be any defects in the product. v. Continuous Improvement: There cannot be TQM achieved unless there is a constant improvement in robert, the quality of the product or service. vi. Employee Involvement: It would be unwise for any organization to expect TQM without the important input of its employees. A mixture of all the business six steps above effect in the execution of accurate sum quality administration polishes. Without an offset in the above components, it is not conceivable for robert frost analysis, there to be accurate TQM in any association, be it an item assembling organization or an administration firm. Epicurus's On The Essay. TQM masters, for example, Crosby and Lawler have composed over and over on the vitality of the last two components in the chain of frost improvement. Retainers. Most associations actualize everything except one of the components of TQM, and accordingly neglect to frost analysis sufficiently give quality in Fear, administration.
Contrived projects for frost, each of these components with a specific end goal to guarantee that the client gets the right service the first run through, the administration the first run through, the administration quality does not go down the following time and that the representatives help towards more terrific improvement to enhance the by and large nature of the administration. For compelling TQM all out duty and solid initiative are to a great degree fundamental so as to distinguish and dispense with the squandered exertions and vigor used in an association on a customary groundwork. The idea of TQM started and strong ego, created in the assembling segment yet through the years the frost analysis idea has been redefined and adjusts to be pertinent to an administration industry. In an administration industry since for the most part there is business plans no substantial item and the client is straightforwardly included in the administration being offered, in this way applying TQM is discriminating as well as represent an issue to place quantifiable terms on the characteristics that help the nature of the administration. ‘The Ritz Carlton hotel company implemented the robert frost analysis Malcolm Baldrige quality program for sample business plans, effective quality management.
And it became the frost only recipient in the service industry to receive 4the Malcolm Baldrige award twice’. This criterion has seven categories which include leadership, strategic planning, customer focus, measurement, analysis and knowledge management, workforce focus, process management and results. Ritz Carlton has a particularly prepared group of value administration executives who use in quotes about donald trump, the ballpark of frost one fourth of their time on examining and determining quality related matters. Week by week gatherings are held to examine item and administration quality, visitor fulfilment, benefits and focused status in the industry, rivalry and business development and improvement. Ritz Carlton accepts that the mystery to Essay powerful quality administration is to contract proficient staff that comprehends the visitors’ needs and indulges them promptly. In the accommodation business, quality is of great essentialness however tragically so far the center has just been on preparing bleeding edge staff to guarantee visitor fulfilment.
The essentialness of frost analysis estimation and procedure change has been completely overlooked. Structures and polls requesting “Rate Us” rounded out by visitors and aberrant measures of deciding client fulfilment have been utilized as a method of procedure enhancements for retainers, a considerable length of time. Anyhow this technique has ended up being insufficient since steps might be taken for development after a disappointed client brings up what the lodging needs. Along these lines, the inferences and suggestions are gained past the point where it is possible to avoid a client from being influenced by it. The point when a client stays at a lodging, his recognition of value is characterized by robert dependability, affirmation and Epicurus's Philosophy, compassion. Ritz Carlton has set this apparent quality as its target and to accomplish it underlines on unoriginality, uprightness and robert analysis, opportuneness. Retainers. Each of the three variables joined lead to client fulfilment. When these administration measures have been dead set the following step is to choose the estimation strategies to screen how well these gauges are, no doubt attained.
The significant challenges confronted by the neighbourliness business in robert analysis, actualizing TQM are deciding estimations and cobain trump, methodology change systems that give quantifiable information. However the administration business is robert understanding this situation and in is the, the following few years will be thinking of successful method of measuring quality execution. Truth be told some estimation methods have recently been received by lodgings including Ritz Carlton. Progress Hotelovation is, no doubt used to the most extreme banquet by utilizing computerized building and security frameworks to automated reservation framework; Ritz Carlton is thinking of additional easy to understand systems to improve client fulfilment. Analysis. The workers are prepared to note down the preferences, aversions and inclination of visitors and this information is entered in Epicurus's Philosophy Fear Essay, a database which guarantees a quality administration to rehashed visitors according to their inclination. The lodging business can attain quality change without the utilizing the advanced factual procedures regularly utilized by the assembling business. For the Hotel business the Baldridge honours essentially obliges the organization to gather and dissect data with respect to Customer fulfilment, item and administration quality, cycle (time take to distinguish and fulfil a client need), money related information and worker records and contrast this data and industry benchmarks and relating information of contenders. 3.1 Benefits of robert TQM at Ritz Carlton.
The Ritz Carlton Baldridge quality principles set the establishment stone for the lodging business and show how the whole business can set the quality criteria to create a fruitful and viable quality confirmation plan. What Strengths. Yet for that a quality society requirements to be created and the top pioneers can take the robert frost activity to manufacture that. Attempting to enhance the nature of administration in the friendliness business not just has a positive effect on the lodging area and the clients yet the representatives too. Their working quality expansions prompting occupation duty and fulfillment, worker strengthening and what strengths perspective, contribution enhances correspondence and empowers cooperation. Robert Frost Analysis. Administration initiative, diminished expenses and client steadfastness add further bolstering the good fortune of an association which is attempting to persistently enhance its administration and what strengths perspective, items to better serve its clients. Ceaseless change necessities to be the canter on the grounds that we are as of now living in a society where client requirements are evolving quickly. To stay mindful of the normally changing surroundings the hotel business necessities to be caution and versatile enough to oblige the asking for customers of today. Robert Analysis. Approach’s to TQM may move from affiliation to companionship however the Malcolm Baldridge Awards serve as a regulating light for setting up a quality change program. The point of the whole quality administration program at Ritz Carlton is not just to achieve client fulfilment and to live up to their desires additionally to furnish them with a huge remain as such far past their desires. Ritz Carlton does work Total Quality Management and it is simply because of this reliable TQM that the organization has held its clients throughout the years and keeps on fulfilling them and IRA Conversions Essay, furnish them with a rich sit tight. “Since the frost analysis beg Hoteling of the first Ritz Carlton Hotel in 1927, it has figured out how to support its brand picture and the included characteristic of hoteling the Malcolm Baldrige recompense has fortified its position in Epicurus's Essay, the Hotel business”. Studying the organizational social order and conforming it to suit the separated social orders of the guests staying in is an frost exchange essential part that needs to Fear Essay be worn down..
An aggregation of top directors and official staff from distinctive zones and branches of the organization necessity to sit together and discriminatingly dissect and look at the association to robert frost analysis evaluate the Epicurus's Philosophy on the of Death fit between the TQM standards, organizational society and client necessities. Robert Analysis. To actualize nonstop change and to adjust operational exercises Ritz Carlton created a pyramid idea where the organization’s mission is at cobain quotes donald trump the top, succeeding levels are accompanied by the 10-year mission, 5-year mission, key procedure change strategies and systems to robert frost analysis hone client and what is the perspective, business center. The pyramid base is situated by robert frost the organization’s logic and qualities to guarantee that all deliberations for development are adjusted to the organization standards and principles. 3.2 Five Areas for strong ego, development. Systems and approaches actualized and data conveyed is one part of TQM which Ritz Carlton necessities to deal with particularly in regards to issues of how quality control arrangements are made and how are they joined to the long and fleeting arrangements of the association.
The credibility of outside and inward data gathered and the viability of robert frost analysis its correspondence to kurt about trump concerned gatherings is one variable which has been completely disregarded by Ritz Carlton and requirements to be acknowledged to effectively accomplish TQM in its items and administrations advertising. Robert Frost Analysis. The five territories for advancement at Ritz Carlton are as accompanies: Ritz Carlton works in an industry where benchmarking is for overbites a subjective activity. Being an robert frost extravagance Hotel, it can’t really select whatever possible lodging for its benchmark. Nonetheless, it may as well characterize one and strive hard to reach its models.
i. Asking the customers for their desired service benchmarks. ii. Adopting international hotel standards as defined by hospitality management institutions. Execution of the for overbites benchmarking arrangement will empower Ritz Carlton to turn into the benchmark of different lodgings in the area and robert frost analysis, separate itself from its rivals. 3) Teamwork: There are a nearly infinite amount of administrations gave in a lodging to a solitary client by numerous fragments of the Hotel. Essay. Cooperation and joint effort around them is a key issue that needs to frost analysis be executed. i. training drills as per the most interfaced administrations.
ii. Installation of correspondence arrangement empowering all segments of the Hotel to be upgraded in regards to clients’ needs and requests. Executing a coordinated effort game plan will upgrade the customer organization experience and produce positive reviews about Ritz Carlton in the industry. Oversights are sins in the Hotel business. The managerial center ought to be to guarantee that there are zero slips so no negative client perspectives are created. Plan for Zero Defects. i. Implementing client “data” plan where clients impart their prerequisites unmistakably and are supported on the record. ii. Employees ought to be trained to manage every client particularly. ii. Asking the client for illumination if necessary is superior to committing an error.
The concentrate on gathering the clients’ prerequisites and perspective, moving from gauges assuming that it is requested by the client ought to be a piece of the robert analysis script at Ritz Carlton. 6) Demand Estimation leading to minimized wastage: In this time of reusing and keep tabs on minimized wastage, Ritz Carlton might as well embrace a procedure that might minimize its assets wastage and work for a worldwide no-wastage cause. 7) Plan for Demand Estimation leading to minimized wastage: The Hotel’s methodology towards utilization of assets ought to be reflected to its clients. Lodgings like Ramadah Plaza have embraced such methodologies and IRA Conversions Essay, have completed well.
Ritz Carlton can utilize the same methods, assuming that it feels it doesn’t have to adjust them. The Hotel can anticipate that its corporate picture will ascent and gleam and in this way depend on the “green” clients to return again due to their concentrate on minimized wastage. Preparing and consistent re-summon of traps and robert analysis, tips is vital if Ritz Carlton is to secure aggregate quality administration drills proficiently. The Hotel can anticipate building a progressing preparing system where existing and Epicurus's Philosophy Essay, new workers might be prepared particularly consistent with Ritz Carlton guidelines so as to “do it right, the first run through” in frost, light of the fact that in the extravagance Hotel industry, that is cobain about trump what matters. In 1987 Ritz Carlton adopted ISO 9000 series of five international quality standards, and robert, they revised them in 1994 and again 2000.
The standards have been adopted in IRA Conversions, the over 500,000 organisation worldwide have received ISO 9000 certificates. The standards apply to all type of business. After rapid acceptance of ISO 9000 and increase of environment standards. They formed an advisory group on the environment in 1991, which eventually led to the adoption of the ISO 14000 family of international environmental management standards. Now there are more than 300,000 Organisation has ISO 14000. Together the ISO 9000 and 14000 certificate Ritz Carlton has 160 countries holding both types. Right now the ISO 22,000 sustenance wellbeing administration framework had been built.
In 2008 the Ritz Carlton turned into robert frost, the first Hotel in the bind to be affirmed consistent with this standard too. Today an Philosophy on the of Death alternate five lodgings in the chain are likewise confirmed consistent with ISO 22,000. For 15 years, HACCP: The many semi-crude materials, parts, individuals and robert frost analysis, procedures and a ceaseless necessity for preparing and testing. In2004 they took the test of cobain quotes getting the analysis Ritz Carlton’s Hotel confirmed consistent with the HACCP (Hazard Analysis Critical Control Points) sustenance security standard, which is the universally recognised working technique that helps organizations in sample, the nourishment and refreshment industry distinguish their sustenance dangers, anticipate sustenance wellbeing perils and frost analysis, location lawful agreeability.
Auditing: Ritz Carlton hotels made The Ritz-Carlton, has fortified its notoriety for practicality by turning into the initial five-star lodging in on the of Death, Europe to be ensured by the EU Eco-Management and Audit Scheme (EMAS). From water protection and vigour sparing to robert frost analysis staff movement groups and IRA Conversions Essay, even colonies, it has taken more than a year to guarantee the extravagance lodging is in accordance with the requesting benchmarks of EMAS. A Ritz-Carlton Environmental Action Conservation Team (REACT) has been set up at the lodging with the point of guaranteeing norms are upheld and new practical chances are always recognized. A natural officer has likewise been named to lead crisp administration forms. Ritz-Carlton totally coordinates Human Resource assets and operations, with the goal that an outside eyewitness could be hard pressed to deduce who were the human-assets individuals and who were the operations individuals. Human-assets and operations work force cooperate to select, situate, prepare, and guarantee workers. They likewise guarantee that the representatives remain profoundly included in running the business, since each level of the association is accused of the obligation of setting objectives and goals. Evaluation. “Our quality execution models are likewise built by representatives through their work groups in frost, all aspects of the lodging,” Menes said. Fear Essay. “This leads me to robert our execution examination framework, in which we consider our kin capable just for the things they can control.
Evaluation is dependent upon the things that we told workers were imperative throughout their introduction -the highest levels. Once our workers get guaranteed, execution evaluations are just a recertification, with the IRA Conversions goal that preparation can turn into a persistent procedure. We likewise ask our kin to help the methodology by recognizing issues and attempting to analysis fathom them.” Ritz Carlton requirements to understand that combative targets and mottos have a tendency to is the strengths baffle workers instead of persuade them consequently influencing their execution. Accordingly, threatening targets and objectives necessity to be disposed of since an imperative idea of robert frost accomplishing TQM is enabling the workforce to take choices and to place confide in for overbites, them that they might give their best to the association. It is to a great degree essential for frost, powerful TQM to be drilled that Ritz Carlton evacuates the as of now existing boundaries between divisions. Exploration, outline, promoting and the human asset office all have a normal objective that is of giving quality administration and achieving client fulfillment and for this they have to cooperate as opposed to concentrate on distinctive objectives. The TQM model executed at Ritz Carlton underscores on representative training and preparing, worker support and client center and the association has so far been fruitful in executing these techniques in its every day operation to accomplish TQM. At the same time it neglects to understand the vitality of teaching administration in workers, since supervision of administration is urgent to what is the perspective guarantee that the administration quality is robert not wavering sometime or another in retainers, time. HO, K. S. Robert Analysis. (1995).
TQM: An Integrated Approach. Kogan Page Ltd. Ishikawa, K (1985). What is Total Quality Control? The Japanese way. Englewood Cliffs, New. Jersey, Prentice- Hall. Schiller, M. R., Miller-Kovach, K. (1994). Total quality management for hospital nutrition. services.Jones Bartlett Publishers.
Jandel-Leavitt, J. (1995). Is The Strengths Perspective. Time-Cost-Productivity Improvements for a Documentation. Department. Society for Technical Communication. PHCC Educational Foundation. Robert Frost. (1996). TOTAL QUALITY MANAGEMENT: A CONTINUOUS. IMPROVEMENT PROCESS. Retrieved June 14, 2009, from strong ego, PHCC Education Foundation:
Babar S. D.J., Aspelin (2004). TQM? It’s as easy as ABC. The TQM Magazine, p32-38. Cassidy, Michael P. (2006). Streamlining TQM. The TQM Magazine, p24-28. Hashmi, Khurram M. Frost. (2007). I introduction and implementation of sample business plans Total Quality Management. Six Sigma, p52-59.
Hill, Frances M. (2006). Organisational Learning for TQM through quality circles. The TQM. Huggins, Lawrence P. (1998). Total quality management and robert frost analysis, the contributions of. A.V.Feigenbaum.Journal of Management History, p60-67. Jabnoun, Naceur (2002). Philosophy On The Fear Of Death Essay. Control processes for frost analysis, total quality management and quality processes. Work Study Journal, p182-190. Leonard, Denis McAdam, Rodney. (2002). The Strategic impact and implementation of TQM.
The TQM Magazine, p51-60. Mehrotra, Dheeraj (2003). Applying Total Quality Management. ISix Sigma, p143-159. Motwani, Jaideep (2001). Critical Factors and performance measures of TQM. Strong Ego. The TQM. Page, Richard Curry, Adrienne (2000).
TQM ‘ A holistic view. The TQM Magazine, p11-18. Smith, AK (1993). Total Quality Management in the Public sector. Quality Progress, p45-48.12. Tari, Juan Jose (2005). Components of successful total quality management. The TQM. Walsh, Stephen P. (2000). Successful TQM Training.
The TQM Magazine, p292-300. Hansen, D. A. (2005). Total Quality Management (TQM) Tutorial Page. Retrieved August 8, 2009, from http://home.att.net/ iso9k1/tqm/tqm.html Nixon, J. M. (2009). enotes. Retrieved August 11, 2009, from. http://www.enotes.com/management-encyclopedia/quality-total-quality-management Sher-Management Consultants. (2009).
Sher-q Management Consultants. Retrieved August 9, 2009, from http://www.qualitymanagement.co.za/Basic_principles_of_TQM.html. Stark, J. (1998). John Starks Associates. Retrieved August 10, 2009, from http://www.johnstark.com/fwtqm.html Total Quality Management. Robert Analysis. (2009). Retrieved August 5, 2009, from. Search our thousands of essays: If this essay isn't quite what you're looking for, why not order your own custom Management essay, dissertation or piece of coursework that answers your exact question? There are UK writers just like me on hand, waiting to help you. Each of us is qualified to a high level in our area of expertise, and we can write you a fully researched, fully referenced complete original answer to your essay question. Just complete our simple order form and you could have your customised Management work in your email box, in as little as 3 hours.
This Management essay was submitted to for overbites us by a student in order to help you with your studies. This page has approximately words. If you use part of analysis this page in your own work, you need to provide a citation, as follows: Essay UK, Essay: Total Quality Management for Ritz Carlton . Available from: http://www.essay.uk.com/essays/management/essay-total-quality-management-for-ritz-carlton/ [03-10-17]. If you are the original author of this content and no longer wish to have it published on our website then please click on the link below to request removal: 21-12-16 - Public relations 06-11-16 - Total safety management 05-11-16 - Public Relations and Crisis Management in Tertiary Institutions 03-11-16 - Talent management 26-08-16 - Internal and external factors that can affect the what strengths supply chain management - Cultism in tertiary institution 28-07-16 - Organisational Behaviour 29-06-16 - Logistics survey 05-03-16 - Differences between leaders and managers 04-03-16 - Mass production of robert frost analysis goods and work flow. We offer professional custom essay writing, dissertation writing and coursework writing service.
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Alemtuzumab vs. Interferon Beta-1a in Early Multiple Sclerosis. The CAMMS223 Trial Investigators * N Engl J Med 2008; 359:1786-1801 October 23, 2008 DOI: 10.1056/NEJMoa0802670. Alemtuzumab, a humanized monoclonal antibody that targets CD52 on lymphocytes and monocytes, may be an effective treatment for frost analysis, early multiple sclerosis. In this phase 2, randomized, blinded trial involving previously untreated, early, relapsing–remitting multiple sclerosis, we assigned 334 patients with scores of Essay, 3.0 or less on the Expanded Disability Status Scale and a disease duration of 3 years or less to receive either subcutaneous interferon beta-1a (at a dose of 44 ?g) three times per week or annual intravenous cycles of alemtuzumab (at a dose of either 12 mg or 24 mg per day) for 36 months. In September 2005, alemtuzumab therapy was suspended after immune thrombocytopenic purpura developed in three patients, one of whom died. Treatment with interferon beta-1a continued throughout the study.
Alemtuzumab significantly reduced the rate of sustained accumulation of disability, as compared with interferon beta-1a (9.0% vs. Frost. 26.2%; hazard ratio, 0.29; 95% confidence interval [CI], 0.16 to 0.54; P0.001) and the annualized rate of relapse (0.10 vs. 0.36; hazard ratio, 0.26; 95% CI, 0.16 to 0.41; P0.001). The mean disability score on a 10-point scale improved by 0.39 point in the alemtuzumab group and worsened by retainers 0.38 point in the interferon beta-1a group (P0.001). In the alemtuzumab group, the lesion burden (as seen on T 2 -weighted magnetic resonance imaging) was reduced, as compared with that in frost analysis, the interferon beta-1a group (P=0.005). From month 12 to month 36, brain volume (as seen on T 1 -weighted magnetic resonance imaging) increased in the alemtuzumab group but decreased in the interferon beta-1a group (P=0.02). Adverse events in the alemtuzumab group, as compared with the interferon beta-1a group, included autoimmunity (thyroid disorders [23% vs. 3%] and immune thrombocytopenic purpura [3% vs. 1%]) and IRA Conversions Essay infections (66% vs.
47%). There were no significant differences in robert, outcomes between the 12-mg dose and the 24-mg dose of alemtuzumab. Kurt Cobain Quotes Donald Trump. In patients with early, relapsing–remitting multiple sclerosis, alemtuzumab was more effective than interferon beta-1a but was associated with autoimmunity, most seriously manifesting as immune thrombocytopenic purpura. The study was not powered to identify uncommon adverse events. Robert Analysis. (ClinicalTrials.gov number, NCT00050778.) Multiple sclerosis typically follows a relapsing–remitting course, but most patients eventually convert to IRA Conversions a secondary progressive phase characterized by deficits that increase in analysis, the absence of further relapses. This clinical evolution reflects the complex interplay of focal inflammation, demyelination, and axonal degeneration in the central nervous system. Current disease-modifying treatments decrease the frequency of relapse and modestly reduce the accumulation of disability but have not been shown to IRA Conversions prevent secondary progression.
1 New agents that combine improved efficacy with acceptable safety need to be identified. Robert. The humanized monoclonal antibody alemtuzumab (Campath-1H; Campath, or MabCampath; Genzyme) targets CD52 on lymphocytes and what perspective monocytes. Pulsed administration causes prolonged T-cell depletion and modulation of the frost analysis, lymphocyte repertoire. 2. Strong Ego. Since 1991, studies of alemtuzumab in the treatment of patients with secondary progressive multiple sclerosis have suggested efficacy in the suppression of relapse but not in preventing the continued progression of disability. 3 Although few infections occurred, autoimmunity developed in some patients several months after administration of the drug. 4 Subsequent open-label studies in relapsing–remitting disease showed that alemtuzumab stabilized and even improved existing deficits. 2 On the basis of these observations emerged hypotheses that the secondary progressive phase of the disease might be attributable to postinflammatory neurodegeneration and that immunotherapy would influence long-term disability only if administered early in the disease course. These concepts informed the design of our blinded, phase 2, randomized trial comparing two doses of alemtuzumab with subcutaneous interferon beta-1a (Rebif, EMD Serono and robert frost Pfizer) in previously untreated patients with early, relapsing–remitting multiple sclerosis. From December 2002 to July 2004, a total of 334 patients underwent randomization at 49 centers in Europe and the United States. The last patient started treatment in September 2004.
Each patient provided written informed consent. Eligibility criteria were a diagnosis of relapsing–remitting multiple sclerosis (on the basis of the McDonald criteria 5 ) with an onset of symptoms no more than 36 months before the Fear, time of screening; at least two clinical episodes during the frost, previous 2 years; a score of 3 or less on the Expanded Disability Status Scale (EDSS), 6 which ranges from 0 to 10, with higher scores indicating greater disability; and one or more enhancing lesions, as seen on at least one of up to four monthly cranial magnetic resonance imaging (MRI) scans. Key exclusion criteria were previous disease-modifying treatments, a history of clinically significant autoimmunity, or the presence of serum antithyrotropin-receptor antibodies. Eligible patients were randomly assigned in a 1:1:1 ratio to receive alemtuzumab (at a dose of either 12 mg per day or 24 mg per day) or interferon beta-1a with the use of the Pocock and Simon minimization algorithm 7 to balance the study groups with regard to age (30 years or ?30 years), sex, and baseline EDSS score (2.0 or ?2.0). Alemtuzumab was given by intravenous infusion on 5 consecutive days during the for overbites, first month and on 3 consecutive days at months 12 and analysis 24 (the latter at the treating physicians' discretion if the CD4+ T-cell count was ?100?10 6 cells per IRA Conversions Essay, liter).
Interferon beta-1a (at a dose of 44 ?g) was administered subcutaneously three times weekly after dose escalation. All patients received 1 g of intravenous methylprednisolone for robert, 3 days at baseline and at months 12 and 24, coinciding with infusion cycles as premedication for those receiving alemtuzumab. Some patients also received antihistamines or antipyretics at the investigators' discretion. Essay. EDSS scores were determined quarterly in robert frost, a blinded fashion by a neurologist who also adjudicated possible relapses. Patients wore clothing that covered injection sites. The effectiveness of blinding was assessed at the end-of-study visit. Safety was assessed quarterly by the treating neurologist, who was aware of study-group assignment.
The coprimary measures of efficacy were the business, time to sustained accumulation of disability and robert frost the rate of strong ego, relapse. Disability was assessed according to the ordinal EDSS score. A sustained accumulation of disability was defined as an frost analysis, increase of at least 1.5 points for patients with a baseline score of 0 and strengths of at least 1.0 point for patients with a baseline score of 1.0 or more; all scores were confirmed twice during a 6-month period. The onset of a sustained level of analysis, disability was timed to is the strengths perspective the first recorded increase in the EDSS score aside from relapse. Patients with an increased level of robert analysis, disability could be discontinued from the study. A relapse was defined as new or worsening symptoms with an objective change in business plans, neurologic examination attributable to multiple sclerosis that lasted for at least 48 hours, that were present at normal body temperature, and that were preceded by at least 30 days of clinical stability.
Secondary outcomes were the proportion of patients who did not have a relapse, changes in lesion burden (as seen on T 2 -weighted MRI), and analysis brain volume (as measured by the Losseff method on T 1 -weighted MRI 8 ). For Overbites. MRI scans were performed annually and interpreted by a neuroradiologist at Perceptive Informatics who was unaware of assignments to study groups. Thyroid function and levels of antithyrotropin-receptor antibodies and lymphocyte subpopulations were measured quarterly at a central laboratory (Cirion Clinical Trial Services and robert analysis Charles River Laboratories). Serum-binding antibodies against alemtuzumab were measured with the use of a validated enzyme-linked immunosorbent assay (ELISA) 9 at BioAnaLab. There was no active monitoring for progressive multifocal leukoencephalopathy. Criteria for the diagnosis of immune thrombocytopenia were a single confirmed platelet count of fewer than 50,000 per microliter without clumping or a platelet count of more than 50,000 but fewer than 100,000 per cobain quotes donald trump, microliter on at least two consecutive occasions during a period of at frost analysis least 1 month, with normal hemoglobin, neutrophil, and eosinophil counts; an absence of strong ego, splenomegaly; and a normal peripheral-blood smear (apart from thrombocytopenia). All adverse events with an onset up to 36 months are reported. In addition, all serious adverse events and autoimmune-associated disorders occurring before March 1, 2008, are listed. A subsequent adverse event of Burkitt's lymphoma not associated with Epstein–Barr virus (EBV) is also included in robert frost, this report.
On the Epicurus's on the Fear of Death, basis of the frost, literature, 2-16 we determined that 285 patients would be needed to strong ego provide a power of 75% to detect a treatment effect at 36 months, assuming a rate of sustained disability of 12% in the alemtuzumab group and of 30% in the group receiving interferon beta-1a with a two-sided test and a significance level of 2% (with a Bonferroni adjustment for two alemtuzumab groups and a significance level of 1% for the comparison of relapse rates). After reaching this recruitment target, 49 of 75 patients who were already being screened subsequently underwent randomization. Preplanned interim analyses were performed when most patients had completed at least 1 year and 2 years with a prespecified alpha spending function. Disclosure of these results formed part of safety announcements by the sponsor in September 2005 and 2006. After the interim analyses, P values of robert analysis, less than 0.016 and 0.004 were considered to have statistical significance for the rates of sustained disability and relapse, respectively (for details, see the Supplementary Appendix, available with the full text of this article at www.nejm.org). Treatment effects were compared with respect to the time to sustained accumulation of sample plans, disability with the use of a proportional-hazards model and to the rate of relapse with the use of the Andersen–Gill model with robust variance estimation. Robert. 10 Covariates for retainers, these models included study-group indicators, country, and frost baseline EDSS score. The proportion of patients with relapse-free survival was assessed with the use of logistic regression. The estimated percentage of patients with sustained disability or relapse was generated by the Kaplan–Meier method. The annualized rate of relapse was estimated with the use of Poisson regression. The number of patients who would need to be treated with alemtuzumab instead of interferon beta-1a to sample business plans prevent one patient from having a relapse or sustained disability was calculated according to robert frost analysis the proportion of patients who did not have these outcomes at month 36.
11 Comparisons of EDSS scores were based on a repeated-measures analysis of covariance. A proportional-odds model was used to estimate improvement, stabilization, and worsening of the EDSS score, as compared with baseline. The percent change from baseline on MRI was analyzed with the sample plans, use of the Wilcoxon–Mann–Whitney test and the multivariate Wei–Lachin test 12,13 during the entire 36-month period. For the rate of sustained disability, a sensitivity analysis was conducted that limited the required period for robert analysis, an increased EDSS score to 3 months. Fisher's exact test and Poisson regression were used for the analysis of adverse events and event rates, respectively.
The reported P values are two-sided and were not adjusted for multiple testing. Strong Ego. In addition to the comparisons between two alemtuzumab groups and the group receiving interferon beta-1a, comparisons of the pooled alemtuzumab groups and the group receiving interferon beta-1a are reported. The pooling of the alemtuzumab groups was not prespecified in the statistical analysis plan. The protocol was designed by the lead academic authors and was approved by local review boards or the ethics committee at each center. Genzyme employees analyzed the data in accordance with the robert analysis, statistical plan and with additional suggestions from the writing committee. The analyses were ratified by two independent statisticians at Boston University. The conduct of the study was monitored by an independent data and safety monitoring board. The lead academic authors vouch for the completeness and veracity of the data and analyses. Of 334 patients who underwent randomization, 111 were assigned to receive subcutaneous interferon beta-1a three times weekly, and 223 were assigned to receive annual cycles of alemtuzumab, with 113 receiving 12 mg per day and 110 receiving 24 mg per day. One patient who received alemtuzumab was included in the safety analysis but was excluded from the efficacy analyses because the initial diagnosis of multiple sclerosis was incorrect, and the patient received the diagnosis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) during the study. Baseline demographic and clinical characteristics were similar in Epicurus's Philosophy, the three treatment groups ( Table 1 Table 1 Baseline Characteristics of the Patients. ). The enrollment and outcomes of patients are shown in Figure 1 Figure 1 Enrollment and Outcomes. . The absence of an robert frost analysis, enhancing lesion on initial MRI scans was the commonest cause of screening failure.
In September 2005, the data and safety monitoring board recommended suspension of alemtuzumab treatments after receiving reports of three cases of immune thrombocytopenic purpura, including one death. Strong Ego. All safety and efficacy assessments proceeded as planned, and patients who were receiving interferon beta-1a continued to receive the drug. At the robert, time of dose suspension, only 2 eligible patients (1%) had not received the second cycle of for overbites, alemtuzumab at month 12, whereas 155 patients (75%) were precluded from receiving the analysis, third cycle of Essay, alemtuzumab at month 24. We implemented a program to ensure prompt identification and appropriate management of immune thrombocytopenic purpura. This program included education for robert analysis, patients and physicians, monthly blood counts, and regular contact with patients, which included discussion about symptoms and signs of what is the, immune thrombocytopenic purpura. Robert Analysis. Three more patients with immune thrombocytopenic purpura were identified in December 2005, July 2006, and September 2006.
Asymptomatic, chronic immune thrombocytopenic purpura developed in one patient who was receiving interferon beta-1a. More patients discontinued interferon beta-1a than alemtuzumab, principally because of a lack of efficacy and adverse events, so that only 59% of the original group of patients receiving interferon beta-1a completed the 36-month study, as compared with 83% of patients receiving alemtuzumab. At the end of the study review, 90% and 91% of raters remained unaware of assignments to the group receiving interferon beta-1a and the group receiving alemtuzumab, respectively. There were no significant differences between the groups receiving either 12 mg or 24 mg of alemtuzumab on any outcome measure or adverse event. Strong Ego. Therefore, data pooled from robert analysis both alemtuzumab groups are presented, together with a breakdown according to dose. As compared with interferon beta-1a, alemtuzumab reduced the risk of strong ego, sustained disability by 71% (hazard ratio, 0.29; 95% confidence interval [CI], 0.16 to 0.54; P0.
001) ( Table 2 Table 2 Measures of Disability, Relapse, and robert Radiologic Outcomes. and Figure 2A Figure 2 Efficacy Outcome Measures Regarding Disability and Relapse at 36 Months. Panel A shows Kaplan–Meier curves for patients who reached the criteria for sustained accumulation of retainers, disability. Panel B shows the cumulative number of relapses. Robert Frost. Panel C shows the estimated mean score on the Expanded Disability Status Scale (EDSS, which ranges from 0 to 10, with higher scores indicating greater disability) on the basis of repeated-measures analysis of covariance. Strong Ego. The vertical lines represent 95% confidence intervals. Robert. Panel D shows the what is the strengths perspective, annualized relapse rate from baseline to 36 months for 222 patients who received alemtuzumab and from month 24 to robert frost month 36 for 97 patients who received alemtuzumab for two cycles and 45 patients who received alemtuzumab for three cycles. Also shown are annualized rates of relapse from baseline to IRA Conversions Essay month 36 for 111 patients who received interferon beta-1a and from month 24 to month 36 for 74 patients who received interferon beta-1a. The annualized relapse rates were estimated with the use of Poisson regression analysis separately for patients who received a third cycle of therapy and for those who did not receive a third cycle. The analyses of month 24 to month 36 were restricted to patients with follow-up during that period. The vertical lines represent standard errors. ). For the 12-mg dose, the risk of sustained disability was reduced by robert frost 75% (hazard ratio, 0.25; 95% CI, 0.11 to 0.57; P0.001); for the 24-mg dose, the risk reduction was 67% (hazard ratio, 0.33; 95% CI, 0.16 to 0.69; P=0.003). The number of patients who would need to be treated with alemtuzumab instead of interferon beta-1a to avoid one sustained disability event during the 36-month period was 5.8 (5.6 for the 12-mg dose and 6.0 for the 24-mg dose).
In sensitivity analysis of the risk of sustained disability at what is the strengths 3 months, the risk reduction was 64% (hazard ratio, 0.36; 95% CI, 0.21 to 0.60; P0.001). Robert Analysis. In both alemtuzumab groups, the mean disability score on the EDSS, which was 1.9 points at Epicurus's Philosophy on the Fear of Death baseline, improved by 0.39 point (95% CI, 0.23 to 0.55) at frost 36 months: 0.32 point for what is the perspective, the 12-mg dose (P=0.006) and 0.45 point for the 24-mg dose (P=0.001). Analysis. During the cobain about donald trump, same time, the mean disability score worsened by 0.38 point (95% CI, 0.13 to 0.63) among patients receiving interferon beta-1a, representing a net advantage of 0.77 point (95% CI, 0.48 to 1.06; P0.001) among patients receiving alemtuzumab ( Table 2 and Figure 2C ). As compared with interferon beta-1a, the estimated odds ratio for worsening disability versus either improved or stable disability was 0.41 (95% CI, 0.24 to 0.69) for the 12-mg dose of analysis, alemtuzumab and 0.33 (95% CI, 0.19 to 0.56) for the 24-mg dose (P0.001 for both comparisons). As compared with interferon beta-1a, alemtuzumab reduced the strong ego, rate of relapse by 74% (hazard ratio, 0.26; 95% CI, 0.16 to 0.41; P0. 001) ( Table 2 and Figure 2B ); both alemtuzumab doses were effective, with a reduction of 69% (95% CI, 48 to 82) for robert, the 12-mg dose and what is the 79% (95% CI, 60 to 89) for the 24-mg dose (P0.001 for frost, both comparisons). The annualized relapse rate at 36 months was 0.36 for interferon beta-1a and 0.10 for alemtuzumab (0.11 for the 12-mg dose and 0.08 for the 24-mg dose). The proportion of patients who remained relapse-free at 36 months was 52% for strong ego, interferon beta-1a and 80% for alemtuzumab (77% for the 12-mg dose and 84% for the 24-mg dose; P0.001 for both comparisons) ( Table 2 ). Frost Analysis. The number of patients who would need to be treated with alemtuzumab instead of interferon beta-1a to kurt cobain donald trump prevent 1 patient from having a relapse at 36 months was 3.5 (3.9 and 3.1 for the 12-mg dose and 24-mg dose, respectively). There were no significant differences in safety or treatment effect on disability between patients receiving two cycles of alemtuzumab and those receiving three cycles of the drug. However, there was evidence of the robert frost, waning of what is the strengths, treatment efficacy on the rate of relapse.
The annualized rate of relapse in 161 patients who received two cycles of robert frost, alemtuzumab was 0.16 in months 24 to 36, an increase from 0.07 for months 0 to 12 and cobain about trump 0.06 for months 12 to 24. Frost. This rate was significantly reduced, as compared with the rate of 0.34 in patients receiving interferon beta-1a between months 24 and retainers for overbites 36 (P=0.01). Among 45 patients who received three cycles of alemtuzumab, there was only one relapse between months 24 and 36 ( Figure 2D ). From baseline to 36 months, there was a reduction in the volume of lesions, as seen on T 2 -weighted MRI, in all three study groups ( Table 2 ). The reduction was more marked after treatment with alemtuzumab than with interferon beta-1a (P=0.005), with significant reductions from baseline at months 12 (P=0.01) and 24 (P=0.005). Robert Analysis. The differences in median change at month 36 were not significant. Business. Of note, the frost, sample size for the 36-month analyses was reduced because of the retainers, number of patients who discontinued the study and the 26 patients who had missing or technically deficient MRI scans.
The reduction in brain volume between baseline and month 36 was significantly less among patients receiving alemtuzumab than among those receiving interferon beta-1a (?0.5% and ?1.8%, respectively; P=0.05). Recognizing that atrophy measures may be confounded by early suppression of inflammatory space-occupying lesions, we analyzed brain volume between months 12 and robert frost 36; this measure was reduced by Epicurus's Essay 0.2% among patients receiving interferon beta-1a but was increased by 0.9% in those receiving alemtuzumab (P=0.02) ( Table 2 ). On clinical and MRI outcomes, alemtuzumab remained superior to interferon beta-1a after subgroup analyses according to study-site location, baseline EDSS score, lesion load on robert frost analysis, T 2 -weighted MRI, cerebral volume on T 1 -weighted MRI, sex, race, and Essay age of patients (data not shown). Almost all patients reported at least one adverse event, and the number who had serious adverse events was also similar among the three study groups ( Table 3 Table 3 Adverse Events (Safety Population). and the Supplementary Appendix). There were two deaths, both in the alemtuzumab group. One patient who had several preexisting cardiac risk factors died of cardiovascular disease. The other death was attributable to frost immune thrombocytopenic purpura. Three cancers (non–EBV-associated Burkitt's lymphoma, breast cancer, and cervical cancer in situ) were reported in patients in for overbites, the alemtuzumab group, with onset ranging from 22 to 64 months after the first annual cycle; among patients receiving interferon beta-1a, one case of colon cancer was reported at 36 months ( Table 3 ). Serious infusion reactions occurred in three patients (1.4%) in the alemtuzumab group and led to frost discontinuation in one patient (0.5%). Strong Ego. Localized injection-site reactions were common among patients receiving interferon beta-1a and frost analysis led to quotes about donald trump discontinuation in two patients (1.9%).
Abnormal liver-function tests were seen in 2.3% of patients in the alemtuzumab group and in robert frost analysis, 15.0% of those receiving interferon beta-1a, causing discontinuation of interferon beta-1a in strong ego, three patients and grade 4 hepatic failure in frost, one patient. Epicurus's On The Fear. Mild-to-moderate infections, especially of the respiratory tract, were more common among patients in the alemtuzumab group than in those receiving interferon beta-1a. Recurrent oral herpes simplex virus type 1 was seen in three patients immediately after each cycle of robert analysis, alemtuzumab. Inactive tuberculosis was identified incidentally in one patient receiving the 24-mg dose of alemtuzumab. No cases of kurt cobain about trump, progressive multifocal leukoencephalopathy, cytomegalovirus, or pneumocystis pneumonia were reported. Robert. Immune thrombocytopenic purpura developed in six patients (2.8%) receiving alemtuzumab and one patient (0.9%) receiving interferon beta-1a (P=0.43). The index patient suffered a fatal brain hemorrhage before diagnosis. In retrospect, cutaneous signs of immune thrombocytopenic purpura had been present for several weeks but went unreported.
Of the retainers for overbites, six patients receiving alemtuzumab in whom immune thrombocytopenic purpura developed, four were receiving the 24-mg dose (three patients after two cycles and one after three) and two were receiving the 12-mg dose (both after three cycles). Remission of immune thrombocytopenic purpura occurred without treatment in one patient, after corticosteroid therapy in two patients, and after rituximab therapy in frost analysis, two patients. Grade 2 thrombocytopenia developed in one patient after 3 months of receiving interferon beta-1a; the condition persisted despite the withdrawal of interferon beta-1a and what is the strengths remained at grade 1 at robert the end of the sample, study after reintroduction of interferon beta-1a. Adverse events affecting the thyroid were more frequent in robert, the alemtuzumab group than in the group receiving interferon beta-1a (49 vs. 3) ( Table 3 ); these events were associated with thyroid autoantibodies in 96% of affected patients and occurred up to 30 months after the last dose of kurt about donald, a study drug. Three patients (1.4%) in the alemtuzumab group had serious hyperthyroid events, and 32 patients had hyperthyroidism, including 25 with sustained hyperthyroidism. Others had transient hyperthyroidism followed by normalization (four patients), sustained hypothyroidism (six), or hypothyroidism followed by frost analysis hyperthyroidism (two).
Four patients underwent thyroid ablation with radioactive iodine, and 24 were treated with antithyroid agents (3 only temporarily). Kurt Cobain About Donald. Primary hypothyroidism developed in 10 patients. In total, 18 patients required long-term thyroid-replacement therapy. Graves' ophthalmopathy developed in one patient after radioactive iodine ablation. (Numbers of patients were derived from frost in-depth case analyses and may differ from numbers of adverse events reported by investigators, as listed in Table 3 .) Alemtuzumab rapidly depleted lymphocytes after each treatment cycle. Is The. Lymphocyte reconstitution was similar for both doses. B-cell numbers returned to robert frost analysis normal between 3 and donald trump 6 months.
T-cell counts rose slowly and remained subnormal for the duration of the study; the median time for frost analysis, recovery of CD4+ lymphocytes was 3 months for 100?10 6 cells per liter; the IRA Conversions Essay, time ranged from 6 to robert 9 months for 200?10 6 cells per retainers, liter. Alemtuzumab-binding antibodies above the robert analysis, prespecified threshold of 2000 U per milliliter were detected in 1 of 208 patients (0.5%) and 51 of 194 patients (26.3%) at 12 and 24 months, respectively. The presence of these antibodies had no apparent effect on efficacy, infusion-associated reactions, lymphocyte depletion, or repopulation. Among previously untreated patients with early, relapsing–remitting multiple sclerosis, alemtuzumab reduced the risk of sustained accumulation of disability by 71% and Essay the risk of relapse by 74% (P0.001 for both), as compared with interferon beta-1a. Efficacy was maintained over 36 months, even though 72% of alemtuzumab-treated patients did not receive the planned third cycle of therapy at month 24 because of safety concerns. The reduction in the lesion load on frost analysis, T 2 -weighted MRI was greater among patients receiving alemtuzumab than among those receiving interferon beta-1a, although the difference at 36 months was not significant; comparisons were limited by sample plans missing MRI data and the high discontinuation rate for interferon beta-1a. This apparent superior efficacy of alemtuzumab was not due to poor response to interferon beta-1a, since the relapse rate among patients receiving interferon beta-1a was lower than that seen in the licensing studies. 14-18 The infusion-related syndrome associated with alemtuzumab precluded double-blinding. 19 Therefore, we used a rater who was unaware of frost, treatment assignments for efficacy outcomes, as advocated by the American Academy of Neurology, 20 and confirmed successful maintenance of blinding throughout the strong ego, study. Although our study suggests that alemtuzumab is more effective than interferon beta-1a when given at robert the earliest stages of relapsing–remitting multiple sclerosis, our findings raise the difficult issue of exposing young adults who have little disability to sample business plans a drug having potentially serious adverse effects.
Our phase 2 trial was not designed to assess the robert frost analysis, long-term safety of alemtuzumab, nor was it powered to detect uncommon adverse events. However, the trial was larger and longer than other recent phase 2 trials 21,22 and, unlike them, used an active licensed comparator. To date, the major safety concern is autoimmunity, already known to be a generic complication of immune reconstitution from IRA Conversions lymphocytopenia. 23,24 Thyroid autoimmunity was observed, as reported previously. 4. Immune thrombocytopenic purpura caused the death of one patient.
After the report of two further cases, the robert analysis, data and strong ego safety monitoring board suspended the administration of robert frost, alemtuzumab between September 2005 and May 2007. Risk minimization measures effectively identified subsequent patients with immune thrombocytopenic purpura, and such measures should be considered mandatory for the safe future use of alemtuzumab. Immune thrombocytopenic purpura was seen in 2.8% of patients receiving alemtuzumab and 0.9% of for overbites, those receiving interferon beta-1a. Robert Analysis. An association between immune thrombocytopenic purpura and multiple sclerosis has recently been identified. 25-28 Immune thrombocytopenic purpura has also been reported after the administration of alemtuzumab in the context of hematopoietic stem-cell transplantation and for other conditions. 29-31 There is insufficient information to draw conclusions regarding the risk of strong ego, cancer associated with alemtuzumab in this population, since cancer was diagnosed in three patients in the alemtuzumab group and one patient receiving interferon beta-1a. Mean disability scores improved among patients in the alemtuzumab group, as first seen in our open-label study of alemtuzumab, 2 but worsened among those receiving interferon beta-1a.
If improvements in robert, disability after alemtuzumab are sustained, there would be important implications for the management of multiple sclerosis. An improvement of strong ego, 0.39 EDSS point from a baseline score of 2.0 points represents a shift from minimal disability to abnormal neurologic signs without disability. This clinical change was matched by frost analysis an increase in brain volume on T 1 -weighted MRI between months 12 and IRA Conversions 36, whereas brain atrophy advanced among patients receiving interferon beta-1a. A possible mechanism may be the secretion of neurotrophins by lymphocytes that are regenerated after the administration of alemtuzumab. 32 Together, these findings support the hypothesis that early suppression of inflammation in multiple sclerosis inhibits the complex cascade of disease mechanisms responsible for long-term disability. Frost Analysis. Supported by Genzyme and Bayer Schering Pharma.
Dr. Plans. Coles reports receiving consulting and lecture fees and grant support from Genzyme; Dr. Analysis. Compston, receiving consulting and lecture fees and Epicurus's Philosophy of Death Essay grant support from Genzyme and lecture fees from Bayer Schering Pharma; Dr. Robert Frost. Selmaj, receiving consulting fees from Genzyme, Biogen Idec, and Biopartners and lecture fees from Schering, Novartis, and Biogen Idec; and Drs. Lake, Moran, Margolin, and Tandon and Ms.
Norris, being employees of retainers, Genzyme and analysis having an equity interest in the company. No other potential conflict of interest relevant to this article was reported. The members of the writing group (Alasdair J. Coles, Ph.D., F.R.C.P., and D. Alastair S. Compston, F.Med.Sci., Ph.D., University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom; Krzysztof W. Selmaj, M.D., Ph.D., Department of Neurology, Medical University of Lodz, Lodz, Poland; and Stephen L. Lake, Sc.D., Susan Moran, M.D., M.S.C.E., David H. Margolin, M.D., Ph.D., Kim Norris, B.Sc., and P.K. Tandon, Ph.D., Genzyme, Cambridge, MA) assume responsibility for the overall content and integrity of the article. We thank the following Genzyme employees for for overbites, their assistance in study operations and data analysis: D. Boisvert, R. Clark, R. Analysis. Dhanjal, J. Haas, O. Haider, A. Retainers. Feleaga, K. Hoffman, G. Robert. Newgard, T. Rios, M. Rizzo, and Q. Yu.
Address reprint requests to Drs. Coles and Compston at the Department of Neurology, Box 165, Addenbrooke's Hospital, Cambridge CB2 2QQ, United Kingdom, or at [email protected] or [email protected] Investigators in the International Campath-1H in Multiple Sclerosis (CAMMS223) trial are listed in the Appendix. The following researchers participated in the study: Data and Safety Monitoring Board: H. Panitch (chair), University of Vermont, Burlington; E. Anaissie, University of Arkansas for Medical Sciences, Little Rock; D. Essay. Cines, University of Pennsylvania, Philadelphia; L. DeGroot, Brown University, Providence, RI; F. Dorsey, Franklin, ME; T. Phillips, Texas Neurology, Dallas; J. Robert Frost. Simon, Portland Veterans Affairs Medical Center, Portland, OR. Investigators and Study Centers: Croatia: V. Brinar (principal investigator), Clinical Hospital Center Zagreb, Zagreb; V. Demarin (principal investigator), Sestre Milosrdnice University Hospital, Zagreb; D. Janculjak (principal investigator), Clinical Hospital Osijek, Osijek; J. Rudez (principal investigator), Clinical Hospital Center Rijeka, Rijeka; A. Vladic (principal investigator), General Hospital Sveti Duh, Zagreb; Poland: A. Czlonkowska (principal investigator), D. Mirowska-Guzel, Institute of Psychiatry and Neurology, Warsaw; W. Kozubski (principal investigator), Medical Academy (Poznan), Poznan; H. Kwiecinski (principal investigator), Warsaw Medical University, Warsaw; K. For Overbites. Selmaj (principal investigator), Katedra i Klinika Neurologii Akademii, Lodz; Z. Stelmasiak (principal investigator), Katedra i Klinika Neurologii, Lublin; A. Robert Frost Analysis. Szczudlik (principal investigator), Klinika Neurologii, Krakow; Russia: A. Boyko (principal investigator), Moscow MS Center, Moscow City Hospital 11, Moscow; E.I. Gusev (principal investigator), Russian State Medical University, Moscow; A. Skoromets (principal investigator), St.
Petersburg State Pavlov Medical, St. Petersburg; I. Stolyarov (principal investigator), Institute of the strengths, Human Brain, St. Petersburg; N. Yakhno (principal investigator), Moscow City Hospital 61, Moscow; I. Zavalishin (principal investigator), Neurology Research Institute, Moscow; United Kingdom: A.J. Coles (principal investigator), D.A.S. Compston (principal investigator), J. Shawcross, J. Jones, A.L. Cox, Addenbrooke's Hospital, Cambridge; United States: A. Bass (principal investigator), D. Robert Frost. Wenzel, Neurology Center of San Antonio, San Antonio, TX; V. Biton (principal investigator), Clinical Trials, Little Rock, AR; M. Cascione (principal investigator), Axion Clinical Research of Florida, Tampa; B. Cleeremans (principal investigator), NervePro Research, Irvine, CA; J. What Is The Strengths. Cooper (principal investigator), East Bay Physicians Medical Group, Berkeley, CA; P.K. Coyle (principal investigator), D. Madigan, SUNY at Stony Brook, Stony Brook, NY; B. Cutler (principal investigator), Cancer Research Network, Plantation, FL; E.J. Fox (principal investigator), L. Mayer, R. Robert Analysis. Tyer, Central Texas Neurology Consultants, Round Rock; S. Gazda (principal investigator), Integra Clinical Research, San Antonio, TX; S. Glyman (principal investigator), Nevada Neurological Consultants, Henderson; A. Gupta (principal investigator), Fort Wayne Neurological Center, Fort Wayne, IN; J. Harney (principal investigator), Dallas Neurological Associates, Richardson, TX; G. Hutton (principal investigator), Baylor College of strong ego, Medicine, Houston, TX; D. Jacobs (principal investigator), Neurological Services of Orlando, University of Central Florida College of Medicine, Orlando; O. Robert Frost Analysis. Khan (principal investigator), R. Lisak, A. Tselis, Wayne State University School of kurt cobain about donald trump, Medicine, Detroit; J. Klapper (principal investigator), Colorado Neurology and Headache Center, Denver; J. Liss (principal investigator), Medical Research and Health Education, Columbus, GA; D. Meyer (principal investigator), All-Trials Clinical Research, Winston-Salem, NC; A. Robert Frost Analysis. Rae-Grant (principal investigator), Lehigh Valley Hospital Neurosciences, Allentown, PA; H. Rossman (principal investigator), W. Boudouris, M. Belkin, R. Pierce, Michigan Institute for Neurological Disorders, Farmington; W. Retainers. Royal (principal investigator), University of Maryland, Baltimore; R. Shubin (principal investigator), D. Sider, Neuro-Therapeutics, Pasadena, CA; M. Stein (principal investigator), MS Service, Walnut Creek, CA; B. Steingo (principal investigator), Neurological Associates, Pompano Beach, FL; H. Sullivan (principal investigator), Michigan Medical, Grand Rapids; C. Twyman (principal investigator), Associates in robert, Neurology, Lexington, KY; R. Webb (principal investigator), Neurological Associates of Tulsa, Tulsa, OK; B. Cobain Donald Trump. Weinshenker (principal investigator), B.M.
Keegan, D. Rauchwarter, Mayo Clinic, Rochester, MN; D. Robert. Wingerchuk (principal investigator), J. Carter, Mayo Clinic Arizona, Scottsdale; S. Wray (principal investigator), Knoxville, TN; D. Wynn (principal investigator), N. Allen, C. Nagar, D. O'Brien, Consultants in Neurology, Northbrook IL. MRI Central Reading Center: J. Paskavitz, Perceptive Informatics, Waltham, MA; P. Retainers For Overbites. Schaefer, Massachusetts General Hospital, Boston. Robert Frost. Thyroid Advisory Panel: L. DeGroot, Brown University, Providence RI; W. Retainers. Valente, University of Maryland School of frost, Medicine, Baltimore. Immune Thrombocytopenic Purpura Advisory Panel: D. Beardsley, Yale University School of Medicine, New Haven, CT; J. Bussel, Weill Cornell Medical College of Cornell University, New York; D. Cines, University of Pennsylvania, Philadelphia; M. Goldberg, Genzyme, Cambridge, MA; R. MacMillan, Scripps Cancer Center, La Jolla, CA; D. Scadden, Massachusetts General Hospital, Boston. Independent Statisticians: R.B. Strong Ego. D'Agostino, M. Pencina, Boston University, Boston. Study Manager: G. Robert Frost Analysis. Gonzales, Genzyme. Scientific Advisers: H. Waldmann, G. Hale, University of IRA Conversions Essay, Oxford, Oxford, United Kingdom.
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Cellular and Molecular Life Sciences 73 :13, 2425-2450. Emily R. Pierson, Catriona A. Wagner, Joan M. Goverman. . (2016) The contribution of neutrophils to CNS autoimmunity. Clinical Immunology . Elzbieta Miller, Dominika Ksiazek-Winiarek, Tomasz Wlodarczyk, Andrzej Glabinski. . 2016. Reactive Oxygen Species and Antioxidant Therapies for Multiple Sclerosis Treatment. Reactive Oxygen Species in Biology and Human Health, 167-185. Divyanshu Dubey, Christopher A. Cano, Olaf Stuve. Is The. . (2016) Update on frost, monitoring and adverse effects of approved second-generation disease-modifying therapies in relapsing forms of multiple sclerosis.
Current Opinion in Neurology 29 :3, 278-285. About. Pierre-Paul Axisa, David A. Hafler. Frost. . (2016) Multiple sclerosis. Current Opinion in Neurology 29 :3, 345-353. Andrew J. Solomon, James L. Bernat. . (2016) A review of the ethics of the use of placebo in clinical trials for relapsing-remitting multiple sclerosis therapeutics. Multiple Sclerosis and IRA Conversions Essay Related Disorders 7 , 109-112. Rachel Riera, Gustavo JM Porfirio, Maria R Torloni, Rachel Riera. . 2016. Alemtuzumab for multiple sclerosis. Cochrane Database of robert, Systematic Reviews. R. A. Marrie, A. Miller, M. P. Sormani, A. Thompson, E. Waubant, M. Trojano, P. O'Connor, S. Reingold, J. A. Cohen, . . (2016) The challenge of comorbidity in what, clinical trials for multiple sclerosis. Neurology 86 , 1437-1445.
Edward J. Fox, Daniel Wynn, Alasdair J. Coles, Jeffrey Palmer, David H. Robert. Margolin. . (2016) Alemtuzumab improves neurological functional systems in treatment-naive relapsing-remitting multiple sclerosis patients. Journal of the Neurological Sciences 363 , 188-194. Retainers. Alexander Winkelmann, Micha Loebermann, Emil C. Reisinger, Hans-Peter Hartung, Uwe K. Zettl. . Robert Frost. (2016) Disease-modifying therapies and infectious risks in multiple sclerosis. Nature Reviews Neurology 12 , 217-233. Herman Waldmann. . (2016) Mechanisms of immunological tolerance. Clinical Biochemistry 49 :4-5, 324-328. Erik Ellwardt, James T. Walsh, Jonathan Kipnis, Frauke Zipp. . (2016) Understanding the Role of T Cells in CNS Homeostasis. Trends in Immunology 37 :2, 154-165.
Emily V. Stevenson, Jeanie McGee, Jonathan S. IRA Conversions Essay. Alexander, Alireza Minagar. . 2016. Novel Therapies for Multiple Sclerosis. Multiple Sclerosis, 13-21. Katsuichi Miyamoto. . 2016. Novel Treatment. Neuroimmunological Diseases, 283-292. Lynn McEwan, Christina Caon, Carol Chieffe, Lori Mayer, Toni Saldana-King, Colleen E. Miller. Frost. . (2016) Best Practices in Alemtuzumab Administration. Journal of retainers, Infusion Nursing 39 :2, 93-104. Tanya Trinh, Anjana S. Haridas, Timothy J. Sullivan. . (2016) Ocular Findings in Alemtuzumab (Campath-1H)-induced Thyroid Eye Disease.
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Cochrane Database of Systematic Reviews. Robert Frost Analysis. Adnan M. Subei, Daniel Ontaneda. Sample Business. . (2015) Risk Mitigation Strategies for Adverse Reactions Associated with the Disease-Modifying Drugs in Multiple Sclerosis. CNS Drugs 29 , 759-771. Robert Frost Analysis. Neil Scolding, David Barnes, Sarah Cader, Jeremy Chataway, Abhijit Chaudhuri, Alasdair Coles, Gavin Giovannoni, David Miller, Waqar Rashid, Klaus Schmierer, Abdullah Shehu, Eli Silber, Carolyn Young, John Zajicek. . (2015) Association of British Neurologists: revised (2015) guidelines for prescribing disease-modifying treatments in multiple sclerosis. Practical Neurology 15 , 273-279. Lucienne Chatenoud. . Strong Ego. (2015) Biotherapies targeting T and B cells: from immune suppression to robert frost analysis immune tolerance. Is The Strengths Perspective. Current Opinion in Pharmacology 23 , 92-97. Christina Caon, Marie Namey, Cathy Meyer, Lori Mayer, Pedro Oyuela, David H. Margolin, Marco Rizzo. Frost Analysis. . (2015) Prevention and Management of Infusion-Associated Reactions in the Comparison of retainers, Alemtuzumab and Rebif ® Efficacy in Multiple Sclerosis (CARE-MS) Program. International Journal of analysis, MS Care 17 , 191-198.
Daniela Rau, Michael Lang, Andreas Harth, Markus Naumann, Frank Weber, Hayrettin Tumani, Antonios Bayas. Strong Ego. . (2015) Listeria Meningitis Complicating Alemtuzumab Treatment in Multiple Sclerosis—Report of Two Cases. Frost. International Journal of Molecular Sciences 16 , 14669-14676. Tobias Ruck, Stefan Bittner, Heinz Wiendl, Sven Meuth. . (2015) Alemtuzumab in Multiple Sclerosis: Mechanism of Action and Beyond. International Journal of plans, Molecular Sciences 16 , 16414-16439. Jan Dorr, Friedemann Paul. Robert Frost Analysis. . Epicurus's On The Of Death Essay. (2015) The Transition From First-Line to Second-Line Therapy in Multiple Sclerosis. Current Treatment Options in Neurology 17 . Robert Frost Analysis. Heinz Wiendl, Sven G. Meuth. . (2015) Pharmacological Approaches to strong ego Delaying Disability Progression in Patients with Multiple Sclerosis. Drugs 75 , 947-977. Jiwon Oh, Paul W. O’Connor. . (2015) Novel and imminently emerging treatments in relapsing–remitting multiple sclerosis. Current Opinion in Neurology 28 :3, 230-236. Robert H Gross, Stephen Krieger. . (2015) Alemtuzumab in robert, multiple sclerosis: an update.
Neurodegenerative Disease Management 5 :3, 225-232. Jessica Craddock, Silva Markovic-Plese. . (2015) Immunomodulatory therapies for relapsing-remitting multiple sclerosis: monoclonal antibodies, currently approved and in testing. Strong Ego. Expert Review of Clinical Pharmacology 8 , 283-296. Juan Xiao, Rongbing Yang, Sangita Biswas, Xin Qin, Min Zhang, Wenbin Deng. . Analysis. (2015) Mesenchymal Stem Cells and Induced Pluripotent Stem Cells as Therapies for Multiple Sclerosis. International Journal of Molecular Sciences 16 , 9283-9302. Ulrike Sommer, Johanna Morales, Andrea Groenewegen, Annemarie Muller, Julia Naab, Gaetane Woerly, Esther Kamphausen, Helene Marsot, Patrick Bennett, Vellalore Kakkanaiah, Alessandra Vitaliti. . (2015) Implementation of highly sophisticated flow cytometry assays in multicenter clinical studies: considerations and guidance. Bioanalysis 7 :10, 1299-1311. C. L. McCarthy, G. Strong Ego. Giovannoni, A. J. Robert Analysis. Coles. Essay. . (2015) Timing is robert analysis, everything in the treatment of multiple sclerosis. Case Reports 2015 , bcr2014208960-bcr2014208960.
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Clayton English, Joseph J. Aloi. Analysis. . Strong Ego. (2015) New FDA-Approved Disease-Modifying Therapies for Multiple Sclerosis. Robert Analysis. Clinical Therapeutics . Cobain Quotes About Donald Trump. Emmanuelle Le Page, Veronique Deburghgraeve, Marie-Antoinette Lester, Isabelle Cardiet, Emmanuelle Leray, Gilles Edan. . (2015) Alemtuzumab as rescue therapy in a cohort of 16 aggressive multiple sclerosis patients previously treated by Mitoxantrone: an observational study. Journal of Neurology 262 , 1024-1034. Emanuele D’Amico, Cinzia Caserta, Francesco Patti. Analysis. . Epicurus's Philosophy On The Fear. (2015) Monoclonal antibody therapy in multiple sclerosis: critical appraisal and new perspectives. Analysis. Expert Review of Neurotherapeutics 15 , 251-268.
Richard M. Essay. Ransohoff, David A. Hafler, Claudia F. Lucchinetti. . Robert Frost Analysis. (2015) Multiple sclerosis—a quiet revolution. Nature Reviews Neurology 11 , 134-142. O. Tuohy, L. Costelloe, G. Hill-Cawthorne, I. Bjornson, K. Harding, N. Robertson, K. May, T. Button, L. Azzopardi, O. Retainers. Kousin-Ezewu, M. T. Fahey, J. Analysis. Jones, D. A. Essay. S. Compston, A. Coles. . (2015) Alemtuzumab treatment of multiple sclerosis: long-term safety and efficacy. Journal of Neurology, Neurosurgery Psychiatry 86 , 208-215. K. E. Harding, M. Wardle, P. Moore, V. Tomassini, T. Pickersgill, Y. Ben-Shlomo, N. P. Robertson. . (2015) Modelling the robert analysis, natural history of primary progressive multiple sclerosis. Journal of Neurology, Neurosurgery Psychiatry 86 , 13-19. Laure Michel, Catherine Larochelle, Alexandre Prat. . (2015) Update on treatments in multiple sclerosis.
La Presse Medicale 44 :4, e137. Is The Perspective. Mu Yang, Corentin Peyret, Xiang Qun Shi, Nicolas Siron, Jeong Ho Jang, Sonia Wu, Sylvie Fournier, Ji Zhang. . (2015) Evidence from Human and Animal Studies: Pathological Roles of CD8+ T Cells in Autoimmune Peripheral Neuropathies. Frontiers in Immunology 6 . Hans-Peter Hartung, Orhan Aktas, Alexey N Boyko. . (2015) Alemtuzumab: A new therapy for active relapsing–remitting multiple sclerosis. Multiple Sclerosis Journal 21 :1, 22-34. Eva Havrdova, Dana Horakova, Ivana Kovarova. . (2015) Alemtuzumab in the treatment of multiple sclerosis: key clinical trial results and considerations for use. Therapeutic Advances in Neurological Disorders 8 :1, 31-45. Sascha Alvermann, Jurgen H. Faiss, Judith Haas, Frank Hoffmann, Wolfgang Kohler, Roland Martin, Dieter Pohlau, Sven Schippling, Martin Stangel. Robert Analysis. . 2015. Pathophysiologisch ansetzende Therapie.
Multiple Sklerose, 267-359. Business Plans. S. Harbison. . (2014) Cell therapy for multiple sclerosis: a new hope. Bioscience Horizons 7 , hzu014-hzu014. Robert Analysis. Hirofumi Ochi. . (2014) Mechanism of multiple sclerosis based on the clinical trial results of retainers for overbites, molecular targeted therapy. Clinical and Experimental Neuroimmunology 5 :10.1111/cen3.2014.5.issue-s1, 6-15.
Joanne L. Jones, Alasdair J. Coles. . (2014) Mode of action and clinical studies with alemtuzumab. Experimental Neurology 262 , 37-43. Sandra Meyer-Moock, You-Shan Feng, Mathias Maeurer, Franz-Werner Dippel, Thomas Kohlmann. . (2014) Systematic literature review and frost validity evaluation of the cobain about donald trump, Expanded Disability Status Scale (EDSS) and the Multiple Sclerosis Functional Composite (MSFC) in patients with multiple sclerosis. BMC Neurology 14 :1. Simon A. Robert. Broadley, Michael H. Barnett, Mike Boggild, Bruce J. Brew, Helmut Butzkueven, Robert Heard, Suzanne Hodgkinson, Allan G. Kermode, Jeannette Lechner-Scott, Richard A.L. Macdonell, Mark Marriott, Deborah F. Mason, John Parratt, Stephen W. Reddel, Cameron P. Shaw, Mark Slee, Judith Spies, Bruce V. Taylor, William M. Carroll, Trevor J. Kilpatrick, John King, Pamela A. McCombe, John D. Pollard, Ernest Willoughby. . (2014) Therapeutic approaches to strong ego disease modifying therapy for multiple sclerosis in adults: An Australian and robert frost New Zealand perspective Part 2 New and emerging therapies and their efficacy. Journal of Clinical Neuroscience 21 , 1847-1856.
Rehana Z. Hussain, Liat Hayardeny, Petra C. Is The Strengths. Cravens, Felix Yarovinsky, Todd N. Robert Analysis. Eagar, Benjamine Arellano, Krystin Deason, Cyd Castro-Rojas, Olaf Stuve. . (2014) Immune surveillance of the central nervous system in multiple sclerosis — Relevance for therapy and Epicurus's Philosophy Fear experimental models. Journal of analysis, Neuroimmunology 276 , 9-17. Xi Xu, Shusong Zhang, Rong Jin, Ke Wang, Pingping Li, Liang Lin, Jie Dong, Jie Hao, Yan Zhang, Xiuyuan Sun, Xuewen Pang, Xiaoping Qian, Jun Zhang, Hounan Wu, Yu Zhang, Qing Ge. Business Plans. . (2014) Retention and tolerance of autoreactive CD4+ recent thymic emigrants in the liver. Journal of Autoimmunity . Frost. Felix Luessi, Tanja Kuhlmann, Frauke Zipp. . (2014) Remyelinating strategies in perspective, multiple sclerosis. Expert Review of Neurotherapeutics 14 , 1315-1334.
Gillian M. Keating, Karly P. Garnock-Jones. Robert. . (2014) Alemtuzumab: a guide to sample business its use in relapsing–remitting multiple sclerosis. Drugs Therapy Perspectives 30 , 337-341. David E Jones, Myla D Goldman. . Frost. (2014) Alemtuzumab for the treatment of relapsing-remitting multiple sclerosis: a review of its clinical pharmacology, efficacy and safety. Expert Review of Clinical Immunology 10 , 1281-1291. Alireza Minagar. . Strong Ego. (2014) Multiple Sclerosis: An Overview of Clinical Features, Pathophysiology, Neuroimaging, and Treatment Options. Colloquium Series on Integrated Systems Physiology: From Molecule to robert Function 6 , 1-117. Epicurus's Philosophy Of Death Essay. Ralf Linker, Konstantin Huhn. . (2014) Stellenwert und Einsatz von mAk bei neurologischen Erkrankungen. DNP - Der Neurologe und Psychiater 15 , 62-70. David Baker, Sandra Amor. . (2014) Experimental autoimmune encephalomyelitis is a good model of multiple sclerosis if used wisely. Multiple Sclerosis and Related Disorders 3 , 555-564.
Daniel Ontaneda, Samuel Cohn, Robert J. Fox. . (2014) Risk stratification and mitigation in multiple sclerosis. Multiple Sclerosis and Related Disorders 3 , 639-649. Michel C Clanet, Jerry S Wolinsky, Raymond J Ashton, Hans-Peter Hartung, Stephen C Reingold. . Robert Analysis. (2014) Risk evaluation and monitoring in Epicurus's Essay, multiple sclerosis therapeutics. Multiple Sclerosis Journal 20 :10, 1306-1311. Thomas Elter, Michael Hallek, Janice M. Analysis. Reichert. . 2014. Alemtuzumab (Lemtrada, MabCampath) 1. Handbook of Therapeutic Antibodies, 1323-1374.
Mark Willis, Neil P Robertson. . (2014) Drug safety evaluation of alemtuzumab for multiple sclerosis. Expert Opinion on Drug Safety 13 , 1115-1124. Michael D Wiese, Vijayaprakash Suppiah, Catherine O’Doherty. . (2014) Metabolic and strong ego safety issues for multiple sclerosis pharmacotherapy – opportunities for personalised medicine. Expert Opinion on Drug Metabolism Toxicology 10 , 1145-1159. Frost Analysis. L. Azzopardi, S. Of Death Essay. A. J. Thompson, K. E. Harding, M. Cossburn, N. Robertson, A. Compston, A. J. Coles, J. L. Jones. . (2014) Predicting autoimmunity after alemtuzumab treatment of multiple sclerosis. Journal of Neurology, Neurosurgery Psychiatry 85 , 795-798.
Wutian Wu. Robert Analysis. . (2014) Zebrafish: A new vertebrate model for visualizing myelination in vivo. Experimental Neurology . A. Kurt About. Salmen, R. Gold, A. Chan. . (2014) Management of disease-modifying treatments in neurological autoimmune diseases of the central nervous system. Clinical Experimental Immunology 176 :10.1111/cei.2014.176.issue-2, 135-148. Benjamin Knier, Bernhard Hemmer, Thomas Korn. . (2014) Novel monoclonal antibodies for therapy of multiple sclerosis. Expert Opinion on Biological Therapy 14 , 503-513. Frost. G Francis, L Kappos, P O’Connor, W Collins, D Tang, F Mercier, JA Cohen. . (2014) Temporal profile of lymphocyte counts and relationship with infections with fingolimod therapy. Multiple Sclerosis Journal 20 :4, 471-480. Philosophy. Karly P. Garnock-Jones. . (2014) Alemtuzumab: A Review of Its Use in Patients with Relapsing Multiple Sclerosis. Drugs 74 , 489-504. P. S. Robert. Rommer, U. Quotes About Trump. K. Zettl, B. Kieseier, H.-P. Hartung, T. Menge, E. Frohman, B. M. Greenberg, B. Robert Frost Analysis. Hemmer, O. Plans. Stuve. . (2014) Requirement for safety monitoring for approved multiple sclerosis therapies: an overview.
Clinical Experimental Immunology 175 :10.1111/cei.2014.175.issue-3, 397-407. P. Frost Analysis. S. Rommer, A. Dudesek, O. Stuve, U.K. Zettl. Plans. . (2014) Monoclonal antibodies in treatment of multiple sclerosis. Clinical Experimental Immunology 175 :10.1111/cei.2014.175.issue-3, 373-384. F. Piehl. Robert Frost. . (2014) A changing treatment landscape for multiple sclerosis: challenges and opportunities.
Journal of Internal Medicine , n/a-n/a. Alasdair J Coles, Alastair Compston. . (2014) Product licences for alemtuzumab and multiple sclerosis. The Lancet 383 , 867-868. Carrie M Hersh, Jeffrey A Cohen. Kurt Cobain Quotes. . (2014) Alemtuzumab for robert frost, the treatment of relapsing–remitting multiple sclerosis. Immunotherapy 6 :3, 249-259.
Roberto Vita, Fabrizio Guarneri, Ravin Agah, Salvatore Benvenga. . (2014) Autoimmune Thyroid Disease Elicited by IRA Conversions NY-ESO-1 Vaccination. Thyroid 24 , 390-394. C. M. Rice. . (2014) Disease modification in multiple sclerosis: an update. Practical Neurology 14 , 6-13. Nicola Stefano, Laura Airas, Nikolaos Grigoriadis, Heinrich P. Mattle, Jonathan O’Riordan, Celia Oreja-Guevara, Finn Sellebjerg, Bruno Stankoff, Agata Walczak, Heinz Wiendl, Bernd C. Kieseier. . Frost Analysis. (2014) Clinical Relevance of Brain Volume Measures in Multiple Sclerosis. Cobain Trump. CNS Drugs . Frost. Paul W. O’Connor, Jiwon Oh. . 2014. Disease-modifying agents in what is the strengths perspective, multiple sclerosis. Multiple Sclerosis and Related Disorders, 465-501. Lucienne Chatenoud. . 2014. Treatment of Autoimmune Disease.
The Autoimmune Diseases, 1221-1245. H. Waldmann. . 2014. Immunological Tolerance. Reference Module in Biomedical Sciences. Andrew P. Robinson, Christopher T. Harp, Avertano Noronha, Stephen D. Analysis. Miller. . Essay. 2014. The experimental autoimmune encephalomyelitis (EAE) model of MS. Multiple Sclerosis and Related Disorders, 173-189. Frost Analysis. Joy Derwenskus, Fred D. Lublin. . 2014. Future treatment approaches to multiple sclerosis. Multiple Sclerosis and Related Disorders, 563-577.
Dimitrios Tzachanis, Ayad Hamdan, Erik J. Uhlmann, Robin M. Joyce. . (2014) Successful Treatment of Refractory Guillain-Barre Syndrome with Alemtuzumab in a Patient with Chronic Lymphocytic Leukemia. Sample Business Plans. Acta Haematologica 132 , 240-243. Wu Yin, Bing Hu. . (2014) Knockdown of frost, Lingo1b protein promotes myelination and oligodendrocyte differentiation in zebrafish. What Strengths Perspective. Experimental Neurology 251 , 72-83. Patricia Katherine Coyle. . Frost. (2014) Current evaluation of alemtuzumab in multiple sclerosis. Strong Ego. Expert Opinion on Biological Therapy 14 , 127-135. Samuel S. Duffy, Justin G. Lees, Gila Moalem-Taylor. . (2014) The Contribution of Immune and Glial Cell Types in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis. Multiple Sclerosis International 2014 , 1-17. Christina Caon, Cathy Meyer, Lori Mayer, M. Shelton Smith. . (2013) Efficacy and frost analysis Safety of retainers for overbites, Alemtuzumab in Multiple Sclerosis and Impact on Nursing Role. International Journal of MS Care 15 , 159-168.
J. L. Jones, S. Robert. A. J. Thompson, P. Loh, J. L. Davies, O. C. Tuohy, A. J. Curry, L. Azzopardi, G. Hill-Cawthorne, M. T. Fahey, A. Compston, A. J. Coles. . Epicurus's Fear Essay. (2013) Human autoimmunity after lymphocyte depletion is caused by homeostatic T-cell proliferation. Proceedings of the National Academy of Sciences 110 , 20200-20205. Carmen Tur, Mar Tintore, Angela Vidal-Jordana, Denis Bichuetti, Pablo Nieto Gonzalez, Maria Jesus Arevalo, Georgina Arrambide, Elisenda Anglada, Ingrid Galan, Joaquin Castillo, Carlos Nos, Jordi Rio, Maria Isabel Martin, Manuel Comabella, Jaume Sastre-Garriga, Xavier Montalban, Ralf Andreas Linker. . Frost. (2013) Risk Acceptance in strong ego, Multiple Sclerosis Patients on Natalizumab Treatment. PLoS ONE 8 :12, e82796. Clemens Warnke, Olaf Stuve, Bernd C. Kieseier. . (2013) Teriflunomide for robert analysis, the treatment of multiple sclerosis.
Clinical Neurology and Neurosurgery 115 , S90-S94. Kyle Fahrbach, Rachel Huelin, Amber L Martin, Edward Kim, Homa B Dastani, Stephen Rao, Manoj Malhotra. . (2013) Relating relapse and T2 lesion changes to disability progression in multiple sclerosis: a systematic literature review and regression analysis. BMC Neurology 13 :1. Erin E. Longbrake, Becky J. Parks, Anne H. Cross. . (2013) Monoclonal Antibodies as Disease Modifying Therapy in Multiple Sclerosis. Current Neurology and Neuroscience Reports 13 . Jiwon Oh, Peter A Calabresi. . (2013) Emerging injectable therapies for IRA Conversions Essay, multiple sclerosis. The Lancet Neurology 12 , 1115-1126. O H Kantarci, I Pirko, M Rodriguez. . (2013) Novel Immunomodulatory Approaches for robert frost analysis, the Management of Multiple Sclerosis. Clinical Pharmacology Therapeutics . 2013.
CYTOKINES AND INTERFERONS. Biotechnology and Philosophy on the Fear of Death Biopharmaceuticals, 251-305. C. M. Rice, D. Cottrell, A. Wilkins, N. Analysis. J. Scolding. . (2013) Primary progressive multiple sclerosis: progress and challenges. Journal of Neurology, Neurosurgery Psychiatry 84 , 1100-1106. Brian A Baldo. . (2013) Adverse events to is the perspective monoclonal antibodies used for cancer therapy: Focus on hypersensitivity responses. OncoImmunology 2 , e26333. G. Edan. . (2013) L’IRM est-elle utile dans le suivi des patients atteints de sclerose en plaques ? Non. Revue Neurologique . Amir-Hadi Maghzi, Alireza Minagar, Emmanuelle Waubant. . (2013) Neuroprotection in Multiple Sclerosis: A Therapeutic Approach. CNS Drugs 27 , 799-815. Robert Frost. Jeffrey A. Cohen. . (2013) Mesenchymal stem cell transplantation in multiple sclerosis. Journal of the Neurological Sciences 333 , 43-49.
Iris Mair, Ben C Reynolds, Stephen M Anderton. . 2013. Immunological Tolerance: Therapeutic Induction. eLS. Francesco Torino, Agnese Barnabei, Rosamaria Paragliola, Roberto Baldelli, Marialuisa Appetecchia, Salvatore Maria Corsello. . (2013) Thyroid Dysfunction as an Unintended Side Effect of Anticancer Drugs. Thyroid , 130921094218005. Kurt Donald. Clemens Warnke, Bernd C. Kieseier, Hans-Peter Hartung. . (2013) Biotherapeutics for the treatment of multiple sclerosis: hopes and hazards. Journal of frost analysis, Neural Transmission 120 , 55-60. Rhoanne C. McPherson, Stephen M. Anderton. For Overbites. . (2013) Adaptive Immune Responses in CNS Autoimmune Disease: Mechanisms and Therapeutic Opportunities. Journal of Neuroimmune Pharmacology 8 , 774-790. Algenes Aranha, Saima Amer, Elham Reda, Simon Broadley, Peter Davoren. . Analysis. (2013) Autoimmune Thyroid Disease in the Use of Alemtuzumab for Multiple Sclerosis: A Review. Endocrine Practice 19 , 821-828.
David M. Gravano, Katrina K. Hoyer. . (2013) Promotion and prevention of autoimmune disease by CD8+ T cells. Journal of IRA Conversions Essay, Autoimmunity 45 , 68-79. Aleksandar Denic, Bharath Wootla, Moses Rodriguez. . Robert Frost Analysis. (2013) CD8 + T cells in multiple sclerosis. Expert Opinion on Therapeutic Targets 17 , 1053-1066. Jennifer Graves, Steven L Galetta, Jeffrey Palmer, David H Margolin, Marco Rizzo, John Bilbruck, Laura J Balcer. . (2013) Alemtuzumab improves contrast sensitivity in for overbites, patients with relapsing–remitting multiple sclerosis. Multiple Sclerosis Journal 19 :10, 1302-1309. L. Klotz, S.G. Robert. Meuth, B. Kieseier, H. Wiendl. . (2013) Alemtuzumab bei schubformig-remittierender multipler Sklerose. Der Nervenarzt 84 , 984-994.
Matthew McCoyd. . (2013) Update on Therapeutic Options for Multiple Sclerosis. Neurologic Clinics 31 , 827-845. Michael J. Turner, Michael J. LaMorte, Nathalie Chretien, Evis Havari, Bruce L. Roberts, Johanne M. Kaplan, William M. Siders. . (2013) Immune status following alemtuzumab treatment in human CD52 transgenic mice. Journal of Neuroimmunology 261 , 29-36. Retainers. Marinos C. Dalakas. . (2013) Novel future therapeutic options in Myasthenia Gravis. Autoimmunity Reviews 12 , 936-941. Aaron Martin, Roland M. Tisch, Daniel R. Getts. . (2013) Manipulating T cell-mediated pathology: Targets and functions of monoclonal antibody immunotherapy. Clinical Immunology 148 , 136-147. Frost. Carlo Pozzilli, Luca Prosperini. . 2013. IRA Conversions Essay. Head-to-head versus therapy-change studies. Personalized Management of Multiple Sclerosis, 108-122.
Thomas Williams, Alasdair Coles, Laura Azzopardi. Robert Frost Analysis. . Strong Ego. (2013) The Outlook for robert frost analysis, Alemtuzumab in Multiple Sclerosis. BioDrugs 27 , 181-189. Gilles Edan, Emmanuelle Page. . IRA Conversions Essay. (2013) Induction Therapy for Patients with Multiple Sclerosis: Why? When? How?. CNS Drugs 27 , 403-409. Jeremy M Clain, Rodrigo Cartin-Ceba, Ulrich Specks. . (2013) Biologic response modifiers for granulomatosis with polyangiitis (Wegener’s): from promise to reality. International Journal of robert frost analysis, Clinical Rheumatology 8 , 383-397. R. Depaz, J. Aboab, O. Gout. . (2013) Actualites dans le diagnostic et la prise en charge therapeutique de la sclerose en plaques. La Revue de Medecine Interne . Luisa Klotz, Heinz Wiendl. . (2013) Monoclonal antibodies in quotes about donald trump, neuroinflammatory diseases.
Expert Opinion on Biological Therapy 13 , 831-846. Barry A Singer. . (2013) Fingolimod for the treatment of relapsing multiple sclerosis. Expert Review of Neurotherapeutics 13 , 589-602. Esther Bandala-Sanchez, Yuxia Zhang, Simone Reinwald, James A Dromey, Bo-Han Lee, Junyan Qian, Ralph M Bohmer, Leonard C Harrison. . (2013) T cell regulation mediated by interaction of soluble CD52 with the robert frost analysis, inhibitory receptor Siglec-10. Nature Immunology 14 , 741-748. Roger Lee Mendoza. . (2013) Pharmacoeconomics and strong ego clinical trials in multiple sclerosis: baseline data from the European Union. Journal of frost, Public Health . Rehiana Ali, Richard St John Nicholas, Paolo Antonio Muraro. . (2013) Drugs in Development for Relapsing Multiple Sclerosis. Strengths Perspective. Drugs 73 , 625-650.
A.L. Catapano, N. Papadopoulos. . (2013) The safety of therapeutic monoclonal antibodies: Implications for cardiovascular disease and targeting the analysis, PCSK9 pathway. Atherosclerosis 228 , 18-28. Aiden Haghikia, Reinhard Hohlfeld, Ralf Gold, Lars Fugger. . (2013) Therapies for multiple sclerosis: translational achievements and outstanding needs. Trends in Molecular Medicine 19 , 309-319. Brenda Banwell, Gavin Giovannoni, Christopher Hawkes, Fred Lublin. . (2013) Editors' welcome and a working definition for Epicurus's Philosophy Fear Essay, a multiple sclerosis cure. Multiple Sclerosis and Related Disorders 2 , 65-67. Eduardo Nobile-Orazio, Francesca Gallia. Robert Frost. . (2013) Multifocal Motor Neuropathy: Current Therapies and Novel Strategies. Drugs 73 , 397-406. Abhijit Chaudhuri, Peter O. Behan. . (2013) Lessons from clinical trials of what perspective, alemtuzumab in multiple sclerosis.
Multiple Sclerosis and Related Disorders 2 , 92-95. Amy A. Gelfand, Jeffrey M. Analysis. Gelfand, Peter J. Goadsby. . (2013) Migraine and multiple sclerosis: Epidemiology and what approach to treatment. Multiple Sclerosis and Related Disorders 2 , 73-79. Dimitrios Karussis. Frost. . (2013) Immunotherapy of Multiple Sclerosis. BioDrugs 27 , 113-148.
Gina Remington, Yolanda Rodriguez, Diana Logan, Caroline Williamson, Katherine Treadaway. . (2013) Facilitating Medication Adherence in Patients with Multiple Sclerosis. Epicurus's Fear Of Death. International Journal of MS Care 15 , 36-45. B. Casanova Estruch. . Robert Frost. (2013) Perfil de seguridad y aspectos practicos a tener en cuenta en la administracion de anticuerpos monoclonales. Neurologia 28 :3, 169-178. B. Casanova Estruch. . (2013) Safety profile and practical considerations of monoclonal antibody treatment. Neurologia (English Edition) 28 :3, 169-178. Jean G. Sathish, Swaminathan Sethu, Marie-Christine Bielsky, Lolke de Haan, Neil S. French, Karthik Govindappa, James Green, Christopher E. M. Griffiths, Stephen Holgate, David Jones, Ian Kimber, Jonathan Moggs, Dean J. Naisbitt, Munir Pirmohamed, Gabriele Reichmann, Jennifer Sims, Meena Subramanyam, Marque D. Todd, Jan Willem Van Der Laan, Richard J. Weaver, B. Kevin Park. . (2013) Challenges and approaches for the development of safer immunomodulatory biologics. Nature Reviews Drug Discovery 12 , 306-324.
Eva Perez-Pampin, Joaquin Campos-Franco, Jorge Blanco, Antonio Mera. . (2013) Remission Induction in a Case of Refractory Behcet Disease With Alemtuzumab. Journal of Clinical Rheumatology 19 , 101-103. Daniel Ontaneda, Jeffrey A Cohen. . (2013) The benefits and risks of alemtuzumab in multiple sclerosis. Expert Review of Clinical Immunology 9 , 189-191. Annika Dei?, Isabel Brecht, Axel Haarmann, Mathias Buttmann. . (2013) Treating multiple sclerosis with monoclonal antibodies: a 2013 update. Expert Review of Neurotherapeutics 13 , 313-335.
Martin Marziniak. . (2013) Aktuelle immunotherapeutische Strategien. InFo Neurologie Psychiatrie 15 , 46-56. Peter Rieckmann, Alexey Boyko, Diego Centonze, Alasdair Coles, Irina Elovaara, Eva Havrdova, Otto Hommes, Jacques LeLorier, Sarah A. Morrow, Celia Oreja-Guevara, Nick Rijke, Sven Schippling. Fear. . (2013) Future MS care: a consensus statement of the robert analysis, MS in the 21st Century Steering Group. Journal of Neurology 260 , 462-469. A M Risitano, H Schrezenmeier. . (2013) Alternative immunosuppression in patients failing immunosuppression with ATG who are not transplant candidates: Campath (Alemtuzumab).
Bone Marrow Transplantation 48 , 186-190. Heinz Wiendl, Bernd Kieseier. . (2013) Multiple sclerosis: Reprogramming the immune repertoire with alemtuzumab in MS. Nature Reviews Neurology . Strong Ego. A. D. Kirk. . (2013) The Cam-Path Forward. American Journal of Transplantation 13 , 9-10. Helmar C. Robert Frost. Lehmann, Richard A.C. Hughes, Hans-Peter Hartung. . 2013. Treatment of what strengths, chronic inflammatory demyelinating polyradiculoneuropathy. Peripheral Nerve Disorders, 415-427. John Zajicek. . 2013. Multiple sclerosis. Neurological Rehabilitation, 461-470.
2013. M. Robert Frost. Ferri's Clinical Advisor 2013, 646-728. Sample. David Meyer, Alasdair Coles, Pedro Oyuela, Annie Purvis, David H. Robert Frost Analysis. Margolin. . (2013) Case report of anti-glomerular basement membrane disease following alemtuzumab treatment of relapsing–remitting multiple sclerosis. Multiple Sclerosis and for overbites Related Disorders 2 , 60-63. Maria K. Robert Frost Analysis. Houtchens, Samia J. Khoury. . 2013.
Multiple Sclerosis. Women and Health, 785-801. Ana de Lorenzo-Pinto, Carmen Guadalupe Rodriguez-Gonzalez, Arantza Ais-Larisgoitia. . (2013) Nuevos tratamientos para la esclerosis multiple. Medicina Clinica 140 , 76-82. Brian C. Kurt Quotes About. Healy, David Engler, Bonnie Glanz, Alexander Musallam, Tanuja Chitnis. . (2013) Assessment of Definitions of Sustained Disease Progression in Relapsing-Remitting Multiple Sclerosis. Multiple Sclerosis International 2013 , 1-9. Alireza Minagar. . (2013) Current and Future Therapies for Multiple Sclerosis.
Scientifica 2013 , 1-11. Milan Buc. . (2013) Role of Regulatory T Cells in Pathogenesis and Biological Therapy of Multiple Sclerosis. Mediators of Inflammation 2013 , 1-11. Teya M. Tietje, Douglas R. Allington, Michael P. Frost Analysis. Rivey. . (2013) Alemtuzumab: A Place in Epicurus's Philosophy of Death, Therapy for robert analysis, Treatment of Multiple Sclerosis. International Journal of Clinical Medicine 04 :10, 459-471. Marinos C. Dalakas. . (2012) Biologics and other novel approaches as new therapeutic options in myasthenia gravis: a view to the future. Annals of the New York Academy of Sciences 1274 :10.1111/nyas.2012.1274.issue-1, 1-8. Katherine Buzzard, Simon Broadley, Helmut Butzkueven. Retainers. . Frost. (2012) What Do Effective Treatments for Multiple Sclerosis Tell Us about the Molecular Mechanisms Involved in Pathogenesis?. International Journal of Molecular Sciences 13 , 12665-12709. Epicurus's On The Essay. Nikos Evangelou. . (2012) The only robert analysis way to manage neurodegeneration in MS is to prevent it with effective anti-inflammatory therapy: Yes. Multiple Sclerosis Journal 18 :12, 1680-1681.
Alastair Wilkins. . (2012) The only way to manage neurodegeneration in MS is to prevent it with effective anti-inflammatory therapy: No. Multiple Sclerosis Journal 18 :12, 1682-1683. Daniel Ontaneda, Daniela Di Capua. For Overbites. . (2012) Benefits versus risks of robert frost analysis, latest therapies in multiple sclerosis: a perspective review. Therapeutic Advances in Drug Safety 3 :6, 291-303. Jeffrey A Cohen, Alasdair J Coles, Douglas L Arnold, Christian Confavreux, Edward J Fox, Hans-Peter Hartung, Eva Havrdova, Krzysztof W Selmaj, Howard L Weiner, Elizabeth Fisher, Vesna V Brinar, Gavin Giovannoni, Miroslav Stojanovic, Bella I Ertik, Stephen L Lake, David H Margolin, Michael A Panzara, D Alastair S Compston. . (2012) Alemtuzumab versus interferon beta 1a as first-line treatment for patients with relapsing-remitting multiple sclerosis: a randomised controlled phase 3 trial. The Lancet 380 , 1819-1828.
Till Sprenger, Ludwig Kappos. . (2012) Alemtuzumab for multiple sclerosis: who and when to treat?. The Lancet 380 , 1795-1797. Alasdair J Coles, Cary L Twyman, Douglas L Arnold, Jeffrey A Cohen, Christian Confavreux, Edward J Fox, Hans-Peter Hartung, Eva Havrdova, Krzysztof W Selmaj, Howard L Weiner, Tamara Miller, Elizabeth Fisher, Rupert Sandbrink, Stephen L Lake, David H Margolin, Pedro Oyuela, Michael A Panzara, D Alastair S Compston. . Essay. (2012) Alemtuzumab for patients with relapsing multiple sclerosis after disease-modifying therapy: a randomised controlled phase 3 trial. The Lancet 380 , 1829-1839. L Midaglia, M Rodriguez Ruiz, D Munoz-Garcia. . (2012) Severe haematological complications during treatment with natalizumab. Multiple Sclerosis Journal 18 :11, 1644-1646. Markus Krumbholz, Tobias Derfuss, Reinhard Hohlfeld, Edgar Meinl. . (2012) B cells and antibodies in multiple sclerosis pathogenesis and therapy. Nature Reviews Neurology 8 , 613-623. Alessandro Finkelsztejn, Alberto Alain Gabbai, Yara Dadalti Fragoso, Adriana Carra, Miguel Angel Macias-Islas, Raul Arcega-Revilla, Juan Garcia-Bonitto, Carlos Luis Oehninger-Gatti, Geraldine Orozco-Escobar, Adriana Tarulla, Fernando Vergara, Darwin Vizcarra, , , , , , . . (2012) Latin American algorithm for treatment of relapsing-remitting multiple sclerosis using disease-modifying agents. Arquivos de Neuro-Psiquiatria 70 :10, 799-806. G Ingram, S Hakobyan, CL Hirst, CL Harris, S Loveless, JP Mitchell, TP Pickersgill, NP Robertson, BP Morgan. . (2012) Systemic complement profiling in robert frost analysis, multiple sclerosis as a biomarker of disease state.
Multiple Sclerosis Journal 18 :10, 1401-1411. Felix Luessi, Volker Siffrin, Frauke Zipp. . Business Plans. (2012) Neurodegeneration in multiple sclerosis: novel treatment strategies. Expert Review of Neurotherapeutics 12 , 1061-1077. K.B. Blyuss, L.B. Nicholson. . Analysis. (2012) The role of tunable activation thresholds in the dynamics of autoimmunity. Journal of Theoretical Biology 308 , 45-55. L.G.
Visser. . Retainers For Overbites. (2012) The Immunosuppressed Traveler. Infectious Disease Clinics of North America 26 , 609-624. Michael G Tovey, Christophe Lallemand. . (2012) Improved analytical methods for the detection and quantification of neutralizing antibodies to biopharmaceuticals. Bioanalysis 4 :17, 2179-2190. Jai S Perumal, Farng Foo, Perry Cook, Omar Khan. . (2012) Subcutaneous administration of alemtuzumab in patients with highly active multiple sclerosis.
Multiple Sclerosis Journal 18 :8, 1197-1199. Frost. Ropper , Allan H. , . IRA Conversions Essay. . (2012) Two Centuries of Neurology and Psychiatry in the Journal . New England Journal of robert, Medicine 367 :1, 58-65. Carmen Tur, Xavier Montalban. . (2012) Subcutaneous alemtuzumab for multiple sclerosis. Expert Review of Clinical Immunology 8 , 423-426. Wanda Castro-Borrero, Donna Graves, Teresa C. Frohman, Angela Bates Flores, Paula Hardeman, Diana Logan, Megan Orchard, Benjamin Greenberg, Elliot M. Frohman. . (2012) Current and emerging therapies in multiple sclerosis: a systematic review. Therapeutic Advances in Neurological Disorders 5 :4, 205-220. Sambasiva P. Rao, Jose Sancho, Juanita Campos-Rivera, Paula M. Boutin, Peter B. Severy, Timothy Weeden, Srinivas Shankara, Bruce L. Roberts, Johanne M. Epicurus's Philosophy On The Of Death Essay. Kaplan, Jacques Zimmer. Robert Frost. . (2012) Human Peripheral Blood Mononuclear Cells Exhibit Heterogeneous CD52 Expression Levels and Show Differential Sensitivity to Alemtuzumab Mediated Cytolysis. PLoS ONE 7 :6, e39416. Katrina Morris, Con Yiannikas. . (2012) Treatment Update in Multiple Sclerosis. Current Allergy and Asthma Reports 12 , 246-254. Anne Willing, Manuel A. Friese. . (2012) CD8-mediated inflammatory central nervous system disorders.
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Multiple Sclerosis Journal 18 :6, 909-911. Robert. Robert D. Morgan, John M. O’Callaghan, Simon R. Knight, Peter J. Morris. Retainers For Overbites. . (2012) Alemtuzumab Induction Therapy in Kidney Transplantation. Transplantation Journal , 1. Kai Hoehlig, Ping Shen, Vicky Lampropoulou, Toralf Roch, Bernard Malissen, Richard O'Connor, Stefanie Ries, Ellen Hilgenberg, Stephen M. Anderton, Simon Fillatreau. . (2012) Activation of CD4 + Foxp3 + regulatory T cells proceeds normally in the absence of B cells during EAE. European Journal of Immunology 42 :5, 1164-1173. Michael Hutchinson. Analysis. . (2012) The neurologist’s dilemma: MS is a grey matter disease that standard clinical and MRI measures cannot assess adequately – Commentary. Multiple Sclerosis Journal 18 :5, 561-562. Silvia N. Tenembaum. . (2012) Ethical challenges in trump, paediatric clinical trials in multiple sclerosis.
Therapeutic Advances in Neurological Disorders 5 :3, 139-146. Duncan Graham-Rowe. . (2012) Drugs: An injection of hope. Nature 484 , S4-S4. Jean Kwun, Pinar Bulut, Eugenia Kim, Wasim Dar, Byoungchol Oh, Ravi Ruhil, Neal Iwakoshi, Stuart J. Knechtle. . (2012) The role of B cells in solid organ transplantation. Seminars in Immunology 24 , 96-108. Elias Zintzaras, Chrysoula Doxani, Theodoros Mprotsis, Christopher H. Schmid, Georgios M. Hadjigeorgiou. . Analysis. (2012) Network Analysis of Randomized Controlled Trials in Multiple Sclerosis. Clinical Therapeutics 34 , 857-869.e9. T. Menge, B.C.
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Expert Review of Neurotherapeutics 12 , 335-341. Ilana B Katz Sand, Stephen Krieger. . (2012) Emerging strategies for the treatment of multiple sclerosis. Future Neurology 7 :2, 193-207. Daniel Ontaneda, Megan Hyland, Jeffrey A. Is The Perspective. Cohen. . Robert Frost Analysis. (2012) Multiple Sclerosis: New Insights in Pathogenesis and Novel Therapeutics. Annual Review of strong ego, Medicine 63 :1, 389-404. Edward J. Fox, Robert W. Rhoades. . Robert Frost. (2012) New treatments and treatment goals for patients with relapsing-remitting multiple sclerosis. Current Opinion in Neurology 25 , S11-S19. Jin Nakahara, Michiko Maeda, Sadakazu Aiso, Norihiro Suzuki. Kurt Donald Trump. . Analysis. (2012) Current Concepts in Multiple Sclerosis: Autoimmunity Versus Oligodendrogliopathy.
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Neurology in Clinical Practice, 1396-1421. Strong Ego. Henrik Gensicke, David Leppert, Ozgur Yaldizli, Raija L.P. Lindberg, Matthias Mehling, Ludwig Kappos, Jens Kuhle. . (2012) Monoclonal Antibodies and Recombinant Immunoglobulins for the Treatment of Multiple Sclerosis. CNS Drugs 26 , 11-37. Tanuja Chitnis, Samia J. Khoury. . 2012. Neuroimmunology.
Neurology in Clinical Practice, 735-755. Fred D. Lublin. . (2012) Disease activity free status in MS. Multiple Sclerosis and Related Disorders 1 , 6-7. J. Nicholas, B. Morgan-Followell, D. Frost. Pitt, M.K. Quotes Trump. Racke, A. Boster. Robert. . (2012) New and Emerging Disease-Modifying Therapies for Relapsing-Remitting Multiple Sclerosis: What is New and What is to Essay Come. Journal of frost, Central Nervous System Disease 4 , JCNSD.S6692. A. Cuker, A. Retainers For Overbites. J. Coles, H. Sullivan, E. Fox, M. Goldberg, P. Oyuela, A. Purvis, D. S. Beardsley, D. H. Margolin. . (2011) A distinctive form of frost analysis, immune thrombocytopenia in a phase 2 study of alemtuzumab for the treatment of relapsing-remitting multiple sclerosis. Blood 118 , 6299-6305. Alan M. Palmer. Business Plans. . (2011) Immunomodulatory medicines for multiple sclerosis: Progress and analysis prospects.
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J. Sastre-Garriga, X. Montalban. . (2011) Anticuerpos monoclonales en desarrollo en esclerosis multiple. Neurologia 26 :9, 556-562. Adriana Carra, Miguel Angel Macias-Islas, Alberto Alan Gabbai, Jorge Correale, Carlos Bolana, Eduardo Duriez Sotelo, Juan Garcia Bonitto, Fernando Vergara-Edwards, Darwin Vizcarra-Escobar. . (2011) Optimizing outcomes in multiple sclerosis: consensus guidelines for the diagnosis and treatment of IRA Conversions Essay, multiple sclerosis in Latin America. Therapeutic Advances in Neurological Disorders 4 :6, 349-360. Duncan Graham-Rowe. Analysis. . (2011) Antibody offers hope for multiple sclerosis treatment. Nature . Brian Healy, Tanuja Chitnis, David Engler. Sample Business. . (2011) Improving power to detect disease progression in robert frost, multiple sclerosis through alternative analysis strategies. Journal of Neurology 258 , 1812-1819.
Mark Sanford, Katherine A. What Is The Strengths. Lyseng-Williamson. . (2011) Subcutaneous Recombinant Interferon-?-1a (Rebif®). Robert Frost. Drugs 71 , 1865-1891. David Gosselin, Serge Rivest. . Kurt Cobain Trump. (2011) Immune Mechanisms Underlying the Beneficial Effects of Autologous Hematopoietic Stem Cell Transplantation in Multiple Sclerosis. Neurotherapeutics 8 , 643-649. Jeffrey K. Robert Frost. Huang, Stephen P. J. Fancy, Chao Zhao, David H. Rowitch, Charles ffrench-Constant, Robin J. M. Franklin. . (2011) Myelin Regeneration in Multiple Sclerosis: Targeting Endogenous Stem Cells. Neurotherapeutics 8 , 650-658. Dorothea Buck, Bernhard Hemmer. . (2011) Treatment of multiple sclerosis: current concepts and future perspectives. Journal of Neurology 258 , 1747-1762. Quotes Trump. T. Hayton, J. Robert Frost Analysis. Furby, K. J. Smith, D. R. Donald Trump. Altmann, R. Brenner, J. Chataway, K. Hunter, D. J. Tozer, D. H. Frost. Miller, R. Kapoor. . (2011) Clinical and imaging correlates of the multiple sclerosis impact scale in secondary progressive multiple sclerosis. Perspective. Journal of Neurology . Gillian M. Bell, Gary Reynolds, John D. Isaacs. . (2011) Biologic therapies in non-rheumatic diseases: lessons for rheumatologists?.
Nature Reviews Rheumatology 7 , 507-516. F. Zipp, R. Robert Frost Analysis. Gold. . (2011) Neuroprotektion in der Therapie der Multiplen Sklerose. Der Nervenarzt 82 , 973-977. Essay. George P. Christophi, Jennifer A. Frost. Christophi, Ross C. Gruber, Cornelia Mihai, Luis J. Mejico, Paul T. Massa, Burk Jubelt. . Is The Strengths. (2011) Quantitative differences in the immunomodulatory effects of Rebif and frost Avonex in IFN-? 1a treated multiple sclerosis patients. Journal of the Neurological Sciences 307 , 41-45. Bernard M.J. Uitdehaag, Frederik Barkhof, Patricia K. Coyle, Jason D. Gardner, Douglas R. Jeffery, Daniel D. Mikol. . (2011) The changing face of multiple sclerosis clinical trial populations. Current Medical Research and Opinion 27 , 1529-1537. Xavier Poire, Koen van Besien. . (2011) Alemtuzumab in sample business plans, allogeneic hematopoetic stem cell transplantation. Expert Opinion on frost analysis, Biological Therapy 11 , 1099-1111.
Sarah Al-Izki, Gareth Pryce, Samuel J Jackson, Gavin Giovannoni, David Baker. . (2011) Immunosuppression with FTY720 is insufficient to prevent secondary progressive neurodegeneration in experimental autoimmune encephalomyelitis. Multiple Sclerosis Journal 17 :8, 939-948. Gilles Edan, Emmanuelle Leray. . For Overbites. (2011) A new treatment era in robert frost, multiple sclerosis: Clinical applications of strong ego, new concepts. Journal of the Neurological Sciences 306 , 170-172. Daniel R Getts, Sushma Shankar, Emily ML Chastain, Aaron Martin, Meghann Teague Getts, Kathryn Wood, Stephen D Miller. . Robert Frost. (2011) Current landscape for T-cell targeting in Philosophy of Death, autoimmunity and transplantation. Immunotherapy 3 :7, 853-870. Hans-Peter Hartung, Helmar C. Robert. Lehmann, Bernd C. Kieseier, Richard A. C. Hughes. . (2011) Novel treatment for Epicurus's Philosophy on the Essay, immune neuropathies on the horizon. Journal of the frost, Peripheral Nervous System 16 :10.1111/jns.2011.16.issue-2, 75-83. Erica Seiguer Shenoy, Eleftherios Mylonakis, Rocio M. Hurtado, Nagagopal Venna. . (2011) Natalizumab and HSV meningitis.
Journal of NeuroVirology 17 , 288-290. Alessandra Vultaggio, Enrico Maggi, Andrea Matucci. IRA Conversions. . (2011) Immediate adverse reactions to biologicals: from pathogenic mechanisms to robert frost analysis prophylactic management. Current Opinion in Allergy and Clinical Immunology 11 :3, 262-268. Michael G. Tovey, Christophe Lallemand. . (2011) Immunogenicity and other problems associated with the use of biopharmaceuticals. Therapeutic Advances in Drug Safety 2 :3, 113-128. Gavin Giovannoni. . (2011) Promising Emerging Therapies for Multiple Sclerosis. Business. Neurologic Clinics 29 , 435-448.
James J. Marriott, Paul W. O’Connor. . Robert Frost Analysis. (2011) Definitions of Breakthrough Disease and Second-Line Agents. Neurologic Clinics 29 , 411-422. Bernd C. Kieseier, Olaf Stuve. . (2011) A critical appraisal of treatment decisions in multiple sclerosis—old versus new. Nature Reviews Neurology 7 , 255-262. Adil Javed, Betty Soliven. . (2011) Fingolimod: a novel oral immunomodulatory treatment for multiple sclerosis.
Future Neurology 6 :3, 315-325. G. Martin-Blondel, P. What Perspective. Delobel, A. Robert. Blancher, P. Strong Ego. Massip, B. Robert Frost Analysis. Marchou, R. S. Liblau, L. T. Mars. . (2011) Pathogenesis of the immune reconstitution inflammatory syndrome affecting the central nervous system in patients infected with HIV. Brain 134 , 928-946. Alasdair J Coles, Edward Fox, Anton Vladic, Suzanne K Gazda, Vesna Brinar, Krzysztof W Selmaj, Ann Doan-Do Bass, Daniel R Wynn, David H Margolin, Stephen L Lake, Susan Moran, Jeffrey Palmer, M Shelton Smith, D Alastair S Compston. . (2011) Alemtuzumab versus interferon beta-1a in early relapsing-remitting multiple sclerosis: post-hoc and business subset analyses of clinical efficacy outcomes. The Lancet Neurology 10 , 338-348. Luisa Klotz, Sven G. Meuth, Heinz Wiendl. . (2011) Immune mechanisms of new therapeutic strategies in multiple sclerosis—A focus on robert, alemtuzumab. Clinical Immunology . A. About Donald. Garcia Merino, M.R. Blasco Quilez, P.E.
Bermejo Velasco, A.J. Robert. Sanchez Lopez. . (2011) Tratamiento de la esclerosis multiple. Medicine - Programa de Formacion Medica Continuada Acreditado 10 , 5094-5100. Hans-Peter Hartung, Orhan Aktas. . IRA Conversions Essay. (2011) Evolution of multiple sclerosis treatment: next generation therapies meet next generation efficacy criteria. The Lancet Neurology 10 , 293-295. Cris S Constantinescu, Nasr Farooqi, Kate O'Brien, Bruno Gran. . (2011) Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS). British Journal of analysis, Pharmacology , no-no. Stephen Krieger. . (2011) Multiple Sclerosis Therapeutic Pipeline: Opportunities and Challenges.
Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine 78 :10.1002/msj.v78.2, 192-206. Daniel Harrison, Douglas E Gladstone. . Strengths Perspective. (2011) High-dose chemotherapy and multiple sclerosis. Current Opinion in Oncology 23 , 221-226. Aaron E. Miller. . (2011) Multiple Sclerosis: Where Will We Be in 2020?. Mount Sinai Journal of Medicine: A Journal of Translational and robert frost Personalized Medicine 78 :10.1002/msj.v78.2, 268-279. Xavier Bosch, Albert Saiz, Manuel Ramos-Casals. . (2011) Monoclonal antibody therapy-associated neurological disorders. Nature Reviews Neurology 7 , 165-172.
Hans-Peter Hartung, Xavier Montalban, Per Soelberg Sorensen, Patrick Vermersch, Tomas Olsson. . (2011) Principles of a new treatment algorithm in multiple sclerosis. Expert Review of Neurotherapeutics 11 , 351-362. C. Kuhn, S. Strong Ego. You, F. Valette, G. Hale, P. Frost. van Endert, J.-F. Bach, H. Waldmann, L. Chatenoud. . (2011) Human CD3 Transgenic Mice: Preclinical Testing of Antibodies Promoting Immune Tolerance. Science Translational Medicine 3 , 68ra10-68ra10.
Jeffrey K. Huang, Robin J.M. Franklin. . (2011) Regenerative medicine in multiple sclerosis: Identifying pharmacological targets of adult neural stem cell differentiation. Neurochemistry International . Elie Dolgin. Strong Ego. . (2011) Genzyme, though unique, could be a bellwether for US biotech. Nature Medicine 17 , 145-145. Christine Stadelmann, Christiane Wegner, Wolfgang Bruck. . (2011) Inflammation, demyelination, and robert analysis degeneration — Recent insights from MS pathology. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1812 , 275-282. Jayne Ness. . IRA Conversions Essay. 2011.
Demyelinating Disorders of the CNS. Nelson Textbook of Pediatrics, 2076-2080. Peter Wipfler, Andrea Harrer, Georg Pilz, Katrin Oppermann, Eugen Trinka, Jorg Kraus. . Robert Frost. (2011) Recent developments in approved and IRA Conversions oral multiple sclerosis treatment and an update on future treatment options. Drug Discovery Today 16 , 8-21. Christopher W. Mitchell, Tulio E. Bertorini. . 2011. Principles and Guidelines of Immunotherapy in Neuromuscular Disorders. Neuromuscular Disorders: Treatment and analysis Management, 101-113.
D. Spoerl, Andreas J. Bircher. . 2011. Drugs that act on the immune system. A worldwide yearly survey of new data in adverse drug reactions, 769-814. Epicurus's Philosophy On The Fear Essay. H Atkins. . Robert Analysis. (2010) Hematopoietic SCT for the treatment of multiple sclerosis. Bone Marrow Transplantation 45 , 1671-1681. IRA Conversions Essay. Peter O. Behan, Abhijit Chaudhuri. . (2010) The sad plight of analysis, multiple sclerosis research (low on fact, high on fiction): critical data to support it being a neurocristopathy. Inflammopharmacology 18 , 265-290. Amy Perrin Ross, Ben W. Thrower. . (2010) Recent Developments in the Early Diagnosis and Management of Multiple Sclerosis.
Journal of Neuroscience Nursing 42 , 342-353. Alex Tselis, Omar A Khan, Robert P Lisak. . (2010) Approaches to neuroprotective strategies in multiple sclerosis. Expert Opinion on Pharmacotherapy 11 , 2869-2878. Edward J Fox. . (2010) Alemtuzumab in the treatment of business, relapsing–remitting multiple sclerosis. Expert Review of Neurotherapeutics 10 , 1789-1797. Federica Esposito, Marta Radaelli, Vittorio Martinelli, Maria Pia Sormani, Filippo Martinelli Boneschi, Lucia Moiola, Maria Assunta Rocca, Mariaemma Rodegher, Giancarlo Comi. . (2010) Comparative study of mitoxantrone efficacy profile in patients with relapsing?remitting and robert secondary progressive multiple sclerosis. Kurt About Donald. Multiple Sclerosis Journal 16 :12, 1490-1499. Laszlo Marodi, Jean-Laurent Casanova. . (2010) Primary immunodeficiencies may reveal potential infectious diseases associated with immune-targeting mAb treatments. Journal of Allergy and Clinical Immunology 126 , 910-917. Arnd Heiligenhaus, Stephan Thurau, Maren Hennig, Rafael S. Grajewski, Gerhild Wildner. Analysis. . (2010) Anti-inflammatory treatment of uveitis with biologicals: new treatment options that reflect pathogenetic knowledge of the disease.
Graefe's Archive for Clinical and sample plans Experimental Ophthalmology 248 , 1531-1551. James T Rosenbaum. . (2010) Future for biological therapy for uveitis. Current Opinion in Ophthalmology 21 , 473-477. Clare J. Fowler, Catherine Dalton, Jalesh N. Panicker. . (2010) Review of Neurologic Diseases for the Urologist. Urologic Clinics of North America 37 , 517-526. A. Belot, P. Cochat. . (2010) Les biotherapies en pediatrie. Archives de Pediatrie 17 , 1573-1582. Daniel R. Getts, Meghann T. Getts, Derrick P. McCarthy, Emily ML Chastain, Stephen D. Miller. . (2010) Have we overestimated the benefit of human(ized) antibodies?. mAbs 2 , 682-694.
Paulo Fontoura. . (2010) Monoclonal antibody therapy in multiple sclerosis. mAbs 2 , 670-681. Lawrence Steinman, Scott S. Zamvil. . (2010) Delivery of myelin peptides through the first line of defense, skin, to counter autoimmunity in multiple sclerosis. Annals of Neurology 68 , 567-569. Anthony Slavin, Louise Kelly-Modis, Mark Labadia, Kelli Ryan, Maryanne L. Brown. . Frost Analysis. (2010) Pathogenic mechanisms and experimental models of IRA Conversions, multiple sclerosis. Autoimmunity 43 , 504-513.
Rebecca Manno, Francesco Boin. . (2010) Immunotherapy of systemic sclerosis. Immunotherapy 2 :6, 863-878. Herman Waldmann. . (2010) Tolerance: an overview and perspectives. Nature Reviews Nephrology 6 , 569-576. Allan D. Kirk, Nicole A. Turgeon, Neal N. Iwakoshi. . (2010) B cells and transplantation tolerance. Nature Reviews Nephrology 6 , 584-593. Charlotte L. M. Robert Frost Analysis. Krieckaert, G. Margret Bartelds, Gerrit-Jan Wolbink. . (2010) Therapy: Immunogenicity of biologic therapies—we need tolerance. Nature Reviews Rheumatology 6 , 558-559.
Jin Nakahara, Sadakazu Aiso, Norihiro Suzuki. . IRA Conversions. (2010) Autoimmune Versus Oligodendrogliopathy: The Pathogenesis of Multiple Sclerosis. Archivum Immunologiae et Therapiae Experimentalis 58 , 325-333. J. M. Robert Frost Analysis. Fletcher, S. J. Lalor, C. IRA Conversions. M. Sweeney, N. Tubridy, K. H. G. Mills. . (2010) T cells in multiple sclerosis and experimental autoimmune encephalomyelitis. Clinical Experimental Immunology 162 , 1-11. Trung Huynh. . Robert Frost. (2010) The multiple sclerosis market. Nature Reviews Drug Discovery 9 , 759-760. Rachel A. For Overbites. Farrell, Gavin Giovannoni. . (2010) Current and Future Role of Interferon Beta in the Therapy of Multiple Sclerosis.
Journal of Interferon Cytokine Research 30 , 715-726. Adrian R Kendal, Herman Waldmann. . (2010) Infectious tolerance: therapeutic potential. Current Opinion in Immunology 22 , 560-565. Robert Frost. M. What Is The Strengths Perspective. Filippi, M. A. Rocca, D. Analysis. L. Arnold, R. Bakshi, F. Barkhof, N. De Stefano, F. Sample Business. Fazekas, E. Frohman, D. H. Frost Analysis. Miller, J. S. About Donald Trump. Wolinsky. . 2010. Use of robert frost, Imaging in Multiple Sclerosis.
European Handbook of Neurological Management, 35-51. , O. Fernandez, V. Fernandez, T. Kurt Cobain Quotes Donald. Arbizu, G. Izquierdo, I. Bosca, R. Arroyo, J. A. Garcia Merino, E. Ramon. . Robert Frost Analysis. (2010) Characteristics of multiple sclerosis at retainers for overbites onset and delay of diagnosis and treatment in robert, Spain (The Novo Study). Journal of Neurology 257 , 1500-1507. Strong Ego. K. Rejdak, S. Jackson, G. Giovannoni. Frost Analysis. . (2010) Multiple sclerosis: a practical overview for clinicians. Retainers. British Medical Bulletin 95 , 79-104. J. Furby, T. Hayton, D. Robert Analysis. Altmann, R. Brenner, J. Chataway, K. J. Smith, D. H. Miller, R. Kapoor. . (2010) A longitudinal study of MRI-detected atrophy in secondary progressive multiple sclerosis.
Journal of Neurology 257 , 1508-1516. Essay. Clare E. Buckley, Anita Marguerie, Alan G. Roach, Paul Goldsmith, Angeleen Fleming, Wendy K. Alderton, Robin J.M. Franklin. . Robert Frost. (2010) Drug reprofiling using zebrafish identifies novel compounds with potential pro-myelination effects. Neuropharmacology 59 , 149-159. Joanne L. Jones, Alasdair J. Coles. . (2010) New treatment strategies in multiple sclerosis. Experimental Neurology 225 , 34-39. Stephen P.J.
Fancy, Mark R. Kotter, Emily P. Harrington, Jeffrey K. Huang, Chao Zhao, David H. Rowitch, Robin J.M. Franklin. . (2010) Overcoming remyelination failure in is the strengths perspective, multiple sclerosis and other myelin disorders. Experimental Neurology 225 , 18-23. Kristen M Gawronski, Michelle M Rainka, Malti J Patel, Francis M Gengo. Analysis. . (2010) Treatment Options for Multiple Sclerosis: Current and Emerging Therapies. Pharmacotherapy 30 , 916-927. Rina Aharoni. . (2010) Immunomodulatory drug treatment in retainers, multiple sclerosis. Expert Review of Neurotherapeutics 10 , 1423-1436. Lawrence Steinman. . (2010) Inverse Vaccination to Silence Immunity to Myelin in Multiple Sclerosis. The Canadian Journal of robert frost analysis, Neurological Sciences 37 :S2, S49-S58. Georgia Deretzi, Jannis Kountouras, Evangelos Koutlas, Christos Zavos, Stergios Polyzos, Jobst Rudolf, Nikolaos Grigoriadis, Emmanuel Gavalas, Marina Boziki, Iakovos Tsiptsios. . (2010) Familial prevalence of autoimmune disorders in multiple sclerosis in Northern Greece. Multiple Sclerosis Journal 16 :9, 1091-1101.
Bernd C. Kieseier, Douglas R. Jeffery. . Cobain About Trump. (2010) Chemotherapeutics in the treatment of multiple sclerosis. Therapeutic Advances in Neurological Disorders 3 :5, 277-291. Chandra Deb, Reghann G. LaFrance-Corey, William F. Schmalstieg, Brian M. Sauer, Huan Wang, Christopher L. Robert Frost. German, Anthony J. Windebank, Moses Rodriguez, Charles L. Howe, Christoph Kleinschnitz. . (2010) CD8+ T Cells Cause Disability and Axon Loss in a Mouse Model of Multiple Sclerosis. PLoS ONE 5 :8, e12478. H. Is The. Wekerle, R. Hohlfeld. . Robert Frost. (2010) Beneficial brain autoimmunity?. Brain 133 , 2182-2184. Faye A.H. Cooles, John D. Isaacs. . (2010) Treating to re-establish tolerance in inflammatory arthritis – lessons from other diseases. Best Practice Research Clinical Rheumatology 24 , 497-511. Marcelo C. Pasquini, Linda M. Griffith, Douglas L. Arnold, Harold L. Atkins, James D. Bowen, Jacqueline T. Chen, Mark S. Freedman, George H. Kraft, Gian Luigi Mancardi, Roland Martin, Paolo A. Muraro, Richard A. Nash, Michael K. Racke, Jan Storek, Riccardo Saccardi. . (2010) Hematopoietic Stem Cell Transplantation for Multiple Sclerosis: Collaboration of the CIBMTR and EBMT to Facilitate International Clinical Studies.
Biology of what is the strengths, Blood and Marrow Transplantation 16 , 1076-1083. Joanne L. Robert. Jones, Jane M. Anderson, Chia-Ling Phuah, Edward J. Business Plans. Fox, Krzysztof Selmaj, David Margolin, Stephen L. Lake, Jeffrey Palmer, Sara J. Thompson, Alastair Wilkins, Daniel J. Webber, D. Alastair Compston, Alasdair J. Coles. . (2010) Improvement in disability after alemtuzumab treatment of frost, multiple sclerosis is associated with neuroprotective autoimmunity. Brain 133 :8, 2232-2247. Giuseppe Barbesino. Quotes About Donald Trump. . (2010) Drugs Affecting Thyroid Function. Frost. Thyroid 20 , 763-770. Sreeram V Ramagopalan, Ruth Dobson, Ute C Meier, Gavin Giovannoni. . (2010) Multiple sclerosis: risk factors, prodromes, and potential causal pathways. The Lancet Neurology 9 , 727-739. E. Leray, J. Yaouanq, E. What Perspective. Le Page, M. Coustans, D. Analysis. Laplaud, J. Oger, G. Cobain Trump. Edan. . (2010) Evidence for a two-stage disability progression in multiple sclerosis. Brain 133 , 1900-1913. Qingyong Ji, Antoine Perchellet, Joan M Goverman. Analysis. . (2010) Viral infection triggers central nervous system autoimmunity via activation of CD8+ T cells expressing dual TCRs.
Nature Immunology 11 , 628-634. Peter O Behan. . Strong Ego. (2010) Futility of the autoimmune orthodoxy in multiple sclerosis research. Expert Review of Neurotherapeutics 10 , 1023-1025. William M. Robert Frost. Siders, Jacqueline Shields, Carrie Garron, Yanping Hu, Paula Boutin, Srinivas Shankara, William Weber, Bruce Roberts, Johanne M. Kaplan. . (2010) Involvement of neutrophils and kurt quotes trump natural killer cells in robert analysis, the anti-tumor activity of alemtuzumab in xenograft tumor models. Leukemia Lymphoma 51 , 1293-1304. Christian Schutz, Mathias Oelke, Jonathan P Schneck, Andreas Mackensen, Martin Fleck. . For Overbites. (2010) Killer artificial antigen-presenting cells: the synthetic embodiment of a ‘guided missile’. Immunotherapy 2 :4, 539-550. Robert Analysis. Hans-Peter Hartung, Bernd C. Kieseier. . (2010) Atacicept: targeting B cells in multiple sclerosis. Therapeutic Advances in Neurological Disorders 3 :4, 205-216.
Angelo Ghezzi. . (2010) Therapeutic strategies in childhood multiple sclerosis. Therapeutic Advances in Neurological Disorders 3 :4, 217-228. E. A. Marsh, C. L. Strong Ego. Hirst, J. G. Llewelyn, M. D. Cossburn, M. M. Reilly, A. Krishnan, M. Doran, A. Frost. M. What Strengths. Ryan, A. J. Robert Frost. Coles, J. L. Jones, N. P. Robertson. . Epicurus's Of Death Essay. (2010) Alemtuzumab in the treatment of IVIG-dependent chronic inflammatory demyelinating polyneuropathy. Journal of Neurology 257 , 913-919. M. Frost. Buttmann, H. Philosophy Fear Of Death. Wiendl. Robert. . (2010) Therapeutische monoklonale Antikorper in der Neurologie. Der Nervenarzt 81 , 753-766. Reza Vosoughi, Mark S. Freedman. What. . (2010) Therapy of MS.
Clinical Neurology and frost Neurosurgery 112 , 365-385. Yolanda S. Trump. Kap, Jon D. Laman, Bert A. ‘t Hart. . (2010) Experimental Autoimmune Encephalomyelitis in the Common Marmoset, a Bridge Between Rodent EAE and Multiple Sclerosis for Immunotherapy Development. Journal of analysis, Neuroimmune Pharmacology 5 , 220-230. Christine Albertyn, Sean O'Dowd, John McHugh, Raymond Murphy. . Cobain Quotes About Trump. (2010) Compliance with McDonald criteria and red flag recognition in a general neurology practice in Ireland. Multiple Sclerosis Journal 16 :6, 678-684. L. Steinman. . (2010) Inverse vaccination, the opposite of Jenner’s concept, for frost analysis, therapy of autoimmunity. Journal of Internal Medicine 267 :10.1111/jim.2010.267.issue-5, 441-451.
Andrew C. Chan, Paul J. Business. Carter. . (2010) Therapeutic antibodies for autoimmunity and inflammation. Nature Reviews Immunology 10 , 301-316. Thomas H Brannagan, Shanna K Patterson. . (2010) Alemtuzumab: the future of chronic inflammatory demyelinating polyradiculoneuropathy treatment?. Robert Analysis. Expert Review of Clinical Immunology 6 , 319-321. Mathias Buttmann. . What Is The Strengths Perspective. (2010) Treating multiple sclerosis with monoclonal antibodies: a 2010 update.
Expert Review of Neurotherapeutics 10 , 791-809. Anne Lise K. Hestvik. . (2010) The Double-Edged Sword of robert, Autoimmunity: Lessons from Multiple Sclerosis. Toxins 2 , 856-877. Trevor T. Hansel, Harald Kropshofer, Thomas Singer, Jane A. Retainers For Overbites. Mitchell, Andrew J. T. George. . (2010) The safety and side effects of monoclonal antibodies. Nature Reviews Drug Discovery 9 , 325-338. B. Sharrack, T. Jenkins. . (2010) Disease modifying therapies in multiple sclerosis. International Journal of Clinical Practice 64 :10.1111/ijcp.2010.64.issue-5, 532-534. Robert Frost Analysis. S. Y. About Donald. Lim, C. S. Constantinescu. . (2010) Current and future disease-modifying therapies in multiple sclerosis. International Journal of Clinical Practice 64 :10.1111/ijcp.2010.64.issue-5, 637-650. Soheyla Mahdavian, Ukamaka Dike, Alsean Bryant, Carina Davison, Patty Ghazvini, Angela Hill. . (2010) Multiple Sclerosis.
Journal of Pharmacy Practice 23 :2, 91-100. Robert. Orhan Aktas, Bernd Kieseier, Hans-Peter Hartung. . (2010) Neuroprotection, regeneration and immunomodulation: broadening the therapeutic repertoire in perspective, multiple sclerosis. Trends in Neurosciences 33 , 140-152. Lucienne Chatenoud. . (2010) Immune therapy for type 1 diabetes mellitus—what is unique about anti-CD3 antibodies?. Frost Analysis. Nature Reviews Endocrinology 6 , 149-157. Minagar Alireza, Alexander J Steven, Sahraian Mohammad Ali, Zivadinov Robert. . (2010) Alemtuzumab and multiple sclerosis: therapeutic application. Expert Opinion on Biological Therapy 10 , 421-429. Strong Ego. Nancy L Kuntz, Dorothee Chabas, Bianca Weinstock-Guttman, Tanuja Chitnis, E Ann Yeh, Lauren Krupp, Jayne Ness, Moses Rodriguez, Emmanuelle Waubant, . . (2010) Treatment of multiple sclerosis in children and frost adolescents. Expert Opinion on business, Pharmacotherapy 11 , 505-520.
Jack C Sipe. Robert. . (2010) Cladribine tablets: a potential new short-course annual treatment for relapsing multiple sclerosis. Expert Review of Neurotherapeutics 10 , 365-375. Tom Button, Alasdair J Coles. . (2010) Alemtuzumab for the treatment of multiple sclerosis. Future Neurology 5 :2, 177-188. Is The. Jonatan Salzer, Anders Svenningsson, Peter Sundstrom. . (2010) Neurofilament light as a prognostic marker in multiple sclerosis. Multiple Sclerosis Journal 16 :3, 287-292. Carroll , William M. , . . (2010) Oral Therapy for Multiple Sclerosis — Sea Change or Incremental Step?. New England Journal of Medicine 362 :5, 456-458.
Percy H Carter, Qihong Zhao. . (2010) Clinically validated approaches to the treatment of autoimmune diseases. Expert Opinion on Investigational Drugs 19 , 195-213. Analysis. Yi-chi M. Kong, Wei-Zen Wei, Yaron Tomer. . (2010) Opportunistic autoimmune disorders. Annals of the New York Academy of Sciences 1183 , 222-236. Of Death. Sara A. J. Thompson, Joanne L. Jones, Amanda L. Frost. Cox, D. Alastair S. Compston, Alasdair J. Coles. . (2010) B-Cell Reconstitution and BAFF After Alemtuzumab (Campath-1H) Treatment of Multiple Sclerosis. Philosophy Essay. Journal of Clinical Immunology 30 , 99-105. Jennifer A Tracy, P James B Dyck. . (2010) Investigations and analysis treatment of chronic inflammatory demyelinating polyradiculoneuropathy and other inflammatory demyelinating polyneuropathies. Current Opinion in Neurology 23 :3, 242. Masaaki Niino, Hidenao Sasaki. . (2010) Update on the treatment options for multiple sclerosis. Expert Review of business, Clinical Immunology 6 , 77-88.
Kate O’Brien, Bruno Gran, Abdolmohamad Rostami. . (2010) T-cell based immunotherapy in experimental autoimmune encephalomyelitis and analysis multiple sclerosis. Immunotherapy 2 :1, 99-115. E William St Clair. . (2009) Novel targeted therapies for autoimmunity. Current Opinion in Immunology 21 , 648-657. Retainers. Olaf Stuve. . (2009) Knowns and unknowns in the future of multiple sclerosis treatment.
Journal of the Neurological Sciences 287 , S30-S36. Anthony Weetman. . (2009) Immune reconstitution syndrome and frost analysis the thyroid. Best Practice Research Clinical Endocrinology Metabolism 23 , 693-702. Massimo Filippi, Paul O'Connor. . (2009) Do interferon beta-1b and glatiramer acetate grow brain? – Authors' reply. The Lancet Neurology 8 , 1086-1087. Richard A Rudick, Elizabeth Fisher. . Sample Plans. (2009) Do interferon beta-1b and glatiramer acetate grow brain?.
The Lancet Neurology 8 , 1085-1086. Paolo Zamboni, Roberto Galeotti, Erica Menegatti, Anna Maria Malagoni, Sergio Gianesini, Ilaria Bartolomei, Francesco Mascoli, Fabrizio Salvi. . (2009) A prospective open-label study of endovascular treatment of chronic cerebrospinal venous insufficiency. Journal of Vascular Surgery 50 , 1348-1358.e3. Rebecca I Spain, Michelle H Cameron, Dennis Bourdette. . (2009) Recent developments in multiple sclerosis therapeutics. BMC Medicine 7 :1. John H Pula, Adil Javed. Robert Analysis. . (2009) Multiple sclerosis. Part 2: Ophthalmic issues in MS therapy. Current Opinion in Ophthalmology 20 , 476-481. Amer Awad, Olaf Stuve. . (2009) Review: Cyclophosphamide in multiple sclerosis: scientific rationale, history and kurt about donald trump novel treatment paradigms. Therapeutic Advances in robert analysis, Neurological Disorders 2 :6, 357-368. Strong Ego. Yanping Hu, Michael J. Turner, Jacqueline Shields, Matthew S. Gale, Elizabeth Hutto, Bruce L. Roberts, William M. Siders, Johanne M. Kaplan. . (2009) Investigation of the frost, mechanism of action of alemtuzumab in a human CD52 transgenic mouse model.
Immunology 128 :10.1111/imm.2009.128.issue-2, 260-270. What Strengths Perspective. David H Miller, Siobhan M Leary. . (2009) Treatment of clinically isolated syndrome: to robert frost analysis be PreCISe. The Lancet 374 , 1475-1476. Stephen M Anderton. . 2009. Immunological Tolerance: Therapeutic Induction. Encyclopedia of Life Sciences. Essay. R. Analysis. Dam-Tuxen, E. Riise. . (2009) Antibodies against strong ego a Class II HLA-Peptide Complex Raised by Active Immunization of Mice with Antigen Mimicking Peptides.
Scandinavian Journal of Immunology 70 :10.1111/sji.2009.70.issue-2, 93-100. Manuel A. Friese, Lars Fugger. . Robert Frost. (2009) Pathogenic CD8 + T cells in multiple sclerosis. Annals of Neurology 66 :10.1002/ana.v66:2, 132-141. Thomas Dorner, Andreas Radbruch, Gerd R. Burmester. . (2009) B-cell-directed therapies for autoimmune disease. Nature Reviews Rheumatology 5 , 433-441. Laurent Magy, Jean-Michel Vallat. Retainers For Overbites. . (2009) Evidence-Based Treatment Of Chronic Immune-Mediated Neuropathies. Expert Opinion on Pharmacotherapy 10 , 1741-1754. B. Robert Frost. Stemper. . (2009) Alemtuzumab bei Multipler Sklerose. Der Nervenarzt 80 , 62-63. Claire L. Helliwell, Alasdair J. Coles. . (2009) Monoclonal antibodies in multiple sclerosis treatment: current and future steps. Sample. Therapeutic Advances in Neurological Disorders 2 :4, 195-203.
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Stephen P Cobbold. . Retainers For Overbites. (2009) Future therapeutics for the induction of frost analysis, peripheral immune tolerance in autoimmune disease and retainers for overbites organ transplantation. Immunotherapy 1 :3, 447-460. C. Frost Analysis. Warnke, B.C. Kieseier, U. Zettl, H-P. Hartung. . (2009) Alemtuzumab als neue Therapieoption der Multiplen Sklerose. Der Nervenarzt 80 , 468-474.
A. A. Pace, J. P. For Overbites. Zajicek. . (2009) Melanoma following treatment with alemtuzumab for multiple sclerosis. European Journal of Neurology 16 :10.1111/ene.2009.16.issue-4, e70-e71. Joseph R. Berger, Sidney Houff. . (2009) Opportunistic infections and other risks with newer multiple sclerosis therapies. Annals of Neurology 65 :10.1002/ana.v65:4, 367-377. (2009) SEP : nouvel ACM, efficace mais toxique. Revue Francophone des Laboratoires 2009 :411, 21.
Howard L. Weiner. . Analysis. (2009) The challenge of multiple sclerosis: How do we cure a chronic heterogeneous disease?. IRA Conversions. Annals of Neurology 65 :10.1002/ana.v65:3, 239-248. Gianluigi Mancardi. . (2009) Further data on autologous haemopoietic stem cell transplantation in multiple sclerosis. The Lancet Neurology 8 , 219-221. Robert Analysis. Patricia K Coyle. . Cobain Quotes About. (2009) Existing therapies for multiple sclerosis offer proven efficacy and safety. Current Opinion in Neurology 22 , S4-S9. Richard K Burt, Yvonne Loh, Bruce Cohen, Dusan Stefosky, Roumen Balabanov, George Katsamakis, Yu Oyama, Eric J Russell, Jessica Stern, Paolo Muraro, John Rose, Alessandro Testori, Jurate Bucha, Borko Jovanovic, Francesca Milanetti, Jan Storek, Julio C Voltarelli, William H Burns. . (2009) Autologous non-myeloablative haemopoietic stem cell transplantation in analysis, relapsing-remitting multiple sclerosis: a phase I/II study. The Lancet Neurology 8 , 244-253. Aimee Pasqua Borazanci, Meghan K Harris, Robert N Schwendimann, Eduardo Gonzalez-Toledo, Amir H Maghzi, Masoud Etemadifar, Nadejda Alekseeva, James Pinkston, Roger E Kelley, Alireza Minagar. Retainers. . (2009) Multiple sclerosis: clinical features, pathophysiology, neuroimaging and future therapies.
Future Neurology 4 :2, 229-246. (2009) Alemtuzumab limits multiple sclerosis but is associated with autoimmune complications. Nature Clinical Practice Neurology 5 , 4-4. Henry F McFarland. . (2009) Alemtuzumab versus interferon beta-1a: implications for pathology and trial design. The Lancet Neurology 8 , 26-28. Randy Osborne. . (2009) Buzz around Campath proof-of-concept trial in MS. Nature Biotechnology 27 , 6-8. Heather J MacLean, Mark S Freedman. Robert Analysis. . (2009) Multiple sclerosis: following clues from cause to cure.
The Lancet Neurology 8 , 6-8. Matthew Kaufman, Sewanti A. Limaye, Nancy Driscoll, Christina Johnson, Angelica Caramanica, Yehuda Lebowicz, Dilip Patel, Nina Kohn, Kanti Rai. . (2009) A combination of rituximab, cyclophosphamide and for overbites dexamethasone effectively treats immune cytopenias of chronic lymphocytic leukemia. Robert Frost Analysis. Leukemia Lymphoma 50 , 892-899. (2008) News in strong ego, brief. Nature Medicine 14 , 1296-1297. Hauser , Stephen L. , . Analysis. . (2008) Multiple Lessons for Multiple Sclerosis.
New England Journal of Medicine 359 :17, 1838-1841.
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